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PLGA多孔球的合成及骨修复性能研究

发表时间:2013-04-15  浏览量:1722  下载量:748
全部作者: 卞春辉,姜萍萍,李晓丰,林惠明,曲凤玉
作者单位: 哈尔滨师范大学化学化工学院
摘 要: 采用乳浊液法,以聚乙烯醇(polyvinyl alcohol,PVA)为分散剂、F127为造孔剂制备出一种具有空心结构的聚乳酸-羟基乙酸共聚物[poly(lactic-co-glycolic acid),PLGA]多孔球。扫描电镜(scanning electron microscope,SEM)测试表明:该球的直径约为20 μm,球表面的大孔孔径约为2.0~2.5 μm;体外模拟体液测试结果表明:该材料可以诱导羟基磷灰石在其表面生长,因而在骨修复领域将具有潜在的应用前景。
关 键 词: 生物无机化学;成骨性能;乳浊液法;聚乳酸-羟基乙酸共聚物;多孔球
Title: Study on the synthesis of PLGA porous microspheres for bone regeneration
Author: BIAN Chunhui, JIANG Pingping, LI Xiaofeng, LIN Huiming, QU Fengyu
Organization: College of Chemistry and Chemical Engineering, Harbin Normal University
Abstract: Poly (lactic-co-glycolic acid) (PLGA) porous microspheres were synthesized using emulsion method. Polyvinyl alcohol (PVA) and F127 were used as dispersing agent and porogen, respectively. The diameter of porous microsphere was about 20 μm. Scanning electron microscope (SEM) showed that the pore size of the macroporous of microsphere was about 2.0-2.5 μm. In vitro simulated body fluid test showed that the porous microspheres could induce the formation of hydroxyapatite on their surface. Therefore, the material may have potential application in tissue regeneration engineering.
Key words: bio-inorganic chemistry; osteogenic; emulsion method; PLGA; porous microspheres
发表期数: 2013年4月第7期
引用格式: 卞春辉,姜萍萍,李晓丰,等. PLGA多孔球的合成及骨修复性能研究[J]. 中国科技论文在线精品论文,2013,6(7):651-654.
 
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