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FABP2 Ala54Thr多态性与结直肠癌易感性的关系

发表时间:2013-06-15  浏览量:1090  下载量:331
全部作者: 徐琳,冯斐,胡晓琴,燕锦,杨艳芳
作者单位: 四川省肿瘤医院肠道外科;四川大学华西公共卫生学院
摘 要: 目的:探讨脂肪酸结合蛋白2(fatty acid binding protein 2,FABP2)Ala54Thr多态性及该基因和环境因素的交互作用与结直肠癌(colorectal cancer,CRC)易感性的关系。方法:采用1:1匹配的病例对照研究,对四川省肿瘤医院151例经组织病理学确诊的CRC新发病例和151例同期未患CRC的健康体检者(对照组)进行问卷调查,收集两组研究对象的一般情况及饮食习惯等资料,应用聚合酶链反应-限制性片段长度多态性(polymerase chain reaction-restriction fragment length polymorphism,PCR-RFLP)分析法检测FABP2 Ala54Thr多态性,采用条件Logistic回归模型分析基因多态性、基因—环境的交互作用与CRC发病风险的关联。结果:FABP2 Ala54Thr的各基因型频率及各等位基因频率在CRC病例组和对照组中分布均无统计学差异(P>0.05)。FABP2 Ala54Thr多态性与食用腌泡菜、食用甜食存在交互作用,其比值比(odds ratio,OR)[95%可信区间(confidence interval,CI)]分别为4.83(1.23~18.89)和2.60(1.15~5.88). 结论:未见FABP2 Ala54Thr多态性与CRC的易感性有关,但FABP2 Ala/Thr及Thr/Thr基因型与环境因素共同作用可能会增加CRC的发病风险。
关 键 词: 流行病学;结直肠癌;基因多态性;脂肪酸结合蛋白2;环境因素;交互作用
Title: Relationship between FABP2 Ala54Thr polymorphism and the risk of colorectal cancer
Author: XU Lin, FENG Fei, HU Xiaoqin, YAN Jin, YANG Yanfang
Organization: Department of Intestinal Surgery, Sichuan Cancer Hospital; West China School of Public Health, Sichuan University
Abstract: Objective: To explore the relationship between the human intestinal fatty acid binding protein 2 (FABP2) Ala54Thr polymorphism as well as gene-environment interaction and colorectal cancer (CRC). Methods: Using a 1:1 matched case-control study to collect the general demography data and eating habits of 151 new cases of CRC and 151 healthy subjects (control) by face-to-face interview. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to detect the FABP2 Ala54Thr genotypes. Conditional logistic regression was used to analyze the relationship between FABP2 Ala54Thr polymorphisms and environmental factors with CRC. Results: There was no statistically significant in the distribution of alleles frequency and genotype frequency between CRC group and control group (P>0.05). However, there were positive interaction between polymorphism of FABP2 Ala54Thr and consumption of pickled vegetables[odds ratio, OR=4.83, 95% confidence interval (CI): 1.23-18.89] and sweet food (OR=2.60, 95%CI: 1.15-5.88). Conclusion: No relationship is found between FABP2 Ala54Thr polymorphisms and CRC. However, the interaction between FABP2 Ala/Thr, Thr/Thr genotype and environmental factors may increase the risk of CRC.
Key words: epidemiology; colorectal cancer; genetic polymorphism; fatty acid binding protein 2; environmental factor; interaction
发表期数: 2013年6月第11期
引用格式: 徐琳,冯斐,胡晓琴,等. FABP2 Ala54Thr多态性与结直肠癌易感性的关系[J]. 中国科技论文在线精品论文,2013,6(11):997-1003.
 
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