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自体吞噬研究进展

发表时间:2013-09-15  浏览量:1360  下载量:520
全部作者: 陶飞,许平
作者单位: 上海交通大学微生物代谢国家重点实验室
摘 要: 自体吞噬(autophagy)是细胞将自己细胞质的一部分(如线粒体和内质网)包围起来形成液泡(自体吞噬泡),再依靠初级溶酶体供应的水解酶将其消化的现象。自体吞噬是细胞维持体内能量和物质平衡的重要手段,是细胞清除变性或冗余蛋白、损害的细胞器以及病原体的手段。研究表明,自体吞噬和人类的健康、疾病以及衰老密切相关,因此自体吞噬是当前细胞生物学和分子生物学的研究热点之一,有望为抗衰老、抗癌等医学难题的攻克提供线索。简要叙述了近年来在自体吞噬研究中取得的进展,主要涉及自体吞噬的分子机理研究,自体吞噬的诱发调控,以及自体吞噬与人类健康和疾病的关系。
关 键 词: 分子生物学;自体吞噬;综述;细胞形态;衰老
Title: Advances of research on autophagy
Author: TAO Fei, XU Ping
Organization: State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University
Abstract: Autophagy is a phenomenon that involves cell degradation of unnecessary or dysfunctional cellular components through the lysosomal machinery. In an autophagy process, the aimed components are enclosed with membrane to form vacuoles (autophagy bubble), and then digest. Autophagy is an important mean for cells to maintain the balance of energy and material. Autophagy is also a cellular strategy to clear away redundant proteins, damaged cellular components and pathogens. Studies have shown that autophagy is closely related to human health, disease, and aging. The relevant research has been one of the hot spots in cell biology and molecular biology. It is expected that autophagy research will provide us clues for overcoming anti-aging, anti-cancer and other big medical problems. This paper briefly describes the progress in the study of autophagy made in recent years, mainly related to the molecular mechanism of autophagy, autophagy regulation, as well as the relationship between autophagy and human health and diseases.
Key words: molecular biology; autophagy; review; cell morphology; aging
发表期数: 2013年9月第17期
引用格式: 陶飞,许平. 自体吞噬研究进展[J]. 中国科技论文在线精品论文,2013,6(17):1593-1599.
 
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