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DCC和netrin在斑马鱼胚胎发育过程中的表达分析

发表时间:2013-09-15  浏览量:850  下载量:476
全部作者: 高景霞,张长稳,张翠珍,彭刚
作者单位: 复旦大学脑科学研究院
摘 要: 为研究斑马鱼前脑神经元的正常投射,用全胚胎原位杂交的方法研究DCC(deleted in colorectal carcinoma)和netrin这对轴突导向因子受体及其配体在斑马鱼胚胎发育过程中的表达情况。结果显示:DCC在斑马鱼前脑背侧神经元有丰富而集中的表达,而netrin在前脑腹侧中线有很强的表达。提示斑马鱼高表达DCC前脑背侧神经元受到前脑腹侧中线netrin的作用实现向腹侧的轴突投射。
关 键 词: 神经生物学;表达;原位杂交;DCC;netrin;斑马鱼
Title: Expression pattern of DCC and netrin in the embryonic zebrafish
Author: GAO Jingxia, ZHANG Changwen, ZHANG Cuizhen, PENG Gang
Organization: Institutes of Brain Science, Fudan University
Abstract: This research focuses on the expression pattern of deleted in colorectal carcinoma (DCC) and netrin in the embryonic zebrafish using whole mount in situ hybridization. DCC and netrin are one of the guidance receptors and ligands. The results showed that DCC are highly expressed in the anterior dorsal neurons in embryonic zebrafish, and netrins are highly expressed in the ventral midline. These results suggest that the axons of the anterior dorsal neurons which express DCC project ventrally guided by the ventral expressed netrins.
Key words: neurobiology; expression; in-situ hybridization; DCC; netrin; zebrafish
发表期数: 2013年9月第17期
引用格式: 高景霞,张长稳,张翠珍,等. DCC和netrin在斑马鱼胚胎发育过程中的表达分析[J]. 中国科技论文在线精品论文,2013,6(17):1628-1631.
 
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