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女贞子防治小鼠酒精性脂肪肝的实验研究

发表时间:2013-12-15  浏览量:1142  下载量:511
全部作者: 杨念云,郭建明,钱大玮
作者单位: 南京中医药大学江苏省方剂高技术研究重点实验室
摘 要: 目的:复制小鼠酒精性脂肪肝(alcoholic fatty liver,AFL)动物模型,观察女贞子对此模型的影响。方法:采用乙醇灌胃致小鼠酒精性肝损伤,同时以女贞子对其进行干预,与正常组对照。喂养30 d后,观察女贞子150,300,600 mg/kg灌胃后小鼠病理组织学改变及肝组织中丙二醛(malondialdehyde,MDA)、还原型谷胱甘肽(glutathione,GSH)和甘油三酯(triglyceride,TG)含量的变化。结果:与模型组相比,女贞子高剂量组肝细胞脂肪变性指数如MDA含量显著降低(P<0.05),TG含量显著降低(P<0.05);中、高剂量组GSH含量明显升高(P<0.01)。结论:女贞子对小鼠AFL有一定防治效果,能减轻脂肪沉积,保肝作用明显。
关 键 词: 中药学;女贞子;酒精性脂肪肝;防治
Title: Experimental study on the control effect of Ligustri lucidi fructus on alcoholic fatty liver disease of mice
Author: YANG Nianyun, GUO Jianming, QIAN Dawei
Organization: Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine
Abstract: Objective: To copy the mice model of alcoholic fatty liver (AFL) and observe the effect of Ligustri lucidi fructus on this animal model. Methods: Mice were exposed to absolute alcohol continuously for up to 30 d via an intragastric feeding and Ligustri lucidi fructus was meanwhile intervened, while the mice in control group were fed normal diet. At the end of experiments, all the mice were sacrificed to analyze malondialdehyde (MDA), glutathione (GSH) and triglyceride (TG) levels in hepatic tissues with the treatments of 150, 300, 600 mg/kg Ligustri lucidi fructus intragastric feeding. Pathological changes of hepatic tissues were also observed under microscope. Results: Compared to AFL model mice, liver MDA (P<0.05) and TG levels (P<0.05) exhibited an obvious reduction in Ligustri lucidi fructus intervened AFL mice, liver GSH levels exhibited an significantly increase in Ligustri lucidi fructus intervened AFL mice (P<0.01). Conclusion: Ligustri lucidi fructus has a significant preventive effect on AFL in mice, which can alleviate fat deposition and improve lipid disorder.
Key words: science of Chinese pharmacology; Ligustri lucidi fructus; alcoholic fatty liver; control effect
发表期数: 2013年12月第23期
引用格式: 杨念云,郭建明,钱大玮. 女贞子防治小鼠酒精性脂肪肝的实验研究[J]. 中国科技论文在线精品论文,2013,6(23):2254-2258.
 
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