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PDTX模型研究进展

发表时间:2014-03-15  浏览量:1817  下载量:726
全部作者: 梁文丰,郑琳,冯韵恬,张灏
作者单位: 中山大学附属第五医院普外科;汕头大学医学院肿瘤研究中心
摘 要: 人源性肿瘤组织异种移植(patient-derived tumor xenograft,PDTX)是一种重要的小鼠肿瘤异种移植模型。这里综述了PDTX模型的分类、模型建立方法、移植肿瘤的传代及影响移植成功率的因素。同时,对PDTX移植肿瘤的生物学特性与原代肿瘤之间的关系,以及PDTX模型在肿瘤学研究中的应用进行总结与展望,旨在为借助这种具有人肿瘤特异性的PDTX模型进行肿瘤个体化治疗时提供理论依据和帮助。
关 键 词: 动物学;人源性肿瘤组织异种移植;综述;原代肿瘤;药物试验
Title: Research progress of PDTX model
Author: LIANG Wenfeng, ZHENG Lin, FENG Yuntian, ZHANG Hao
Organization: Department of General Surgery, The Fifth Affiliated Hospital of Sun Yat-sen University; Cancer Research Center of Shantou University Medical College
Abstract: Patient-derived tumor xenograft (PDTX) is an important model of tumor xenograft for mice. This paper reviewed the classification, establishment, generation of tumor xenograft and impact factors for successful transplanting of PDTX model. At the same time, this paper summaried and prospected the biological characters and the relationship of primary tumors of PDTX model, and the application of PDTX model in tumor research as well. This review provided theory evidence and help for individualized treatment for tumor based on PDTX model which had human tumor characters.
Key words: zoology; patient-derived tumor xenograft; review; primary tumor; drug trial
发表期数: 2014年3月第5期
引用格式: 梁文丰,郑琳,冯韵恬,等. PDTX模型研究进展[J]. 中国科技论文在线精品论文,2014,7(5):398-402.
 
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