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果蝇脑中短神经肽F受体(sNPFR1)的结构与分布

发表时间:2014-09-15  浏览量:1293  下载量:527
全部作者: 陈文锋,赵章武
作者单位: 中国农业大学农学与生物技术学院
摘 要: 蘑菇体(mushroom body, MB)是昆虫脑部的一个重要中枢神经,对高级记忆等具有重要的调控作用。果蝇脑部蘑菇体中发现有大量的短神经肽F(short neuropeptide F, sNPF)表达,但是关于sNPF受体(sNPF receptor 1,sNPFR1)在果蝇蘑菇体的分布还不清楚。研究首次对sNPFR1的结构进行分析,发现sNPFR1是典型的G蛋白偶联受体,具有7次跨膜结构。同时,对sNPF及sNPFR1在脑部蘑菇体的共定位进行研究,发现sNPFR1也分布在蘑菇体上,但是与sNPF的分布表现出差异性。
关 键 词: 昆虫学;果蝇遗传学;短神经肽F;短神经肽F受体
Title: Structure and distribution of short neuropeptide F receptor (sNPFR1) in the brain of Drosophila melanogaster
Author: CHEN Wenfeng, ZHAO Zhangwu
Organization: College of Agriculture and Biotechnology, China Agricultural University
Abstract: The mushroom body is a prominent set of bilateral neuropils in the insect brain, known to be a memory control center in which the short neuropeptide F (sNPF) is expressed. However, the distribution of its receptor (sNPF receptor 1, sNPFR1) in mushroom bodies remains unknown. In this paper, we analyze the structure of sNPFR1 and found it’s a classic G-coupled protein that contains seven transmembrane structures. We also co-localized sNPF and sNPFR1 in mushroom bodies and find that sNPFR1 also distributes in mushroom bodies, but different with the distribution of sNPF.
Key words: entomology; drosophila genetics; short neuropeptide F; short neuropeptide F receptir 1
发表期数: 2014年9月第17期
引用格式: 陈文锋,赵章武. 果蝇脑中短神经肽F受体(sNPFR1)的结构与分布[J]. 中国科技论文在线精品论文,2014,7(17):1752-1756.
 
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