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中药抑制良性前列腺增生作用机制研究进展

发表时间:2014-12-15  浏览量:1799  下载量:663
全部作者: 陶蕊,苗琳,樊官伟,王虹,王跃飞,蒋晓蕊,柴丽娟
作者单位: 天津中医药大学天津市现代中药重点实验室;天津中医药大学天津市中药药理学重点实验室
摘 要: 良性前列腺增生症(benign prostatic hyperplasia,BPH)已成为高龄男性的常见病、多发病,药物治疗是缓解BPH症状的重要手段。我国传统中药(traditional Chinese medicine,TCM)相比于西药在治疗BPH中具有临床效果显著、不良反应小、可长期服用等优势。近年来,随着研究的不断深入,发现并鉴定了一批对BPH有效的TCM单体或复方的作用靶点,主要包括5α-还原酶,雌、雄激素受体,α-肾上腺素能受体等,其作用机制主要与影响雌/雄激素的水平及两者之间的平衡、抑制细胞的增殖、降低生长因子的合成表达、诱导细胞的凋亡以及改善下尿路症状等有关。综述为将来研制新型、安全、有效的TCM提供了参考资料。
关 键 词: 中药学;良性前列腺增生;综述;雌激素;雄激素
Title: Research progress on the mechanism of inhibiting benign prostatic hyperplasia by traditional Chinese medicine
Author: TAO Rui, MIAO Lin, FAN Guanwei, WANG Hong, WANG Yuefei, JIANG Xiaorui, CHAI Lijuan
Organization: Tianjin Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine; Tianjin Key Laboratory of Chinese Medical Pharmacology, Tianjin University of Traditional Chinese Medicine
Abstract: Benign prostatic hyperplasia (BPH) is a common disease with high incidence in elder men, while the main treatment of which is medication. Compared with the Western medicine, the traditional Chinese medicine (TCM) have not only shown their clinical effectiveness,but the advantages on their long-term use and less adverse effect have also been recognized. Several targets such as 5α-reductase, estrogen receptor, androgen receptor, and α-adrenergic receptor have been revealed that TCM played the important roles in the process of the monomers or compounds for BPH treatment. The mechanisms consists of the regulation of estrogen/androgen levels, their balance between estrogen and androgen, suppression of cell proliferation, down-regulation of growth factor expressions, induction of cell apoptosis, improvement of the lower urinary-tract symptoms condition. This review may provide developing more innovative, safe and effective medicine in future.
Key words: traditional Chinese pharmacology; benign prostatic hyperplasia; review; estrogen; androgen
发表期数: 2014年12月第23期
引用格式: 陶蕊,苗琳,樊官伟,等. 中药抑制良性前列腺增生作用机制研究进展[J]. 中国科技论文在线精品论文,2014,7(23):2307-2316.
 
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