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响应面分析法优化蔷薇红景天多酚提取工艺
发表时间：2014-12-15 浏览量：1939 下载量：727
| 全部作者： | 赵岩，赵天琦，蔡恩博，许永华，刘双利，杨鹤，张连学 |
| 作者单位： | 吉林农业大学中药材学院 |
| 摘 要： | 目的：研究蔷薇红景天多酚的最佳提取工艺条件。方法：利用响应面法（response surface method，RSM）对蔷薇红景天多酚的提取工艺进行优化。在单因素实验的基础上，选择乙醇浓度、超声提取时间和液固比为自变量，多酚提取率为响应值，根据中心组合实验设计原理采用3因素5水平的响应面分析法，研究各自变量及其交互作用对多酚提取率的影响，模拟得到二次多项式回归方程的预测模型，并对最优条件进行验证。结果：在分析各因素的显著性和交互作用后，得出蔷薇红景天多酚的最佳提取工艺为：乙醇浓度48%（体积比)，超声时间40 min，液固比286 mL/g. 结论：在最佳工艺条件下，蔷薇红景天多酚提取率为11.59%（质量比）. 研究建立的模型适合蔷薇红景天多酚提取，可用于实际生产。 |
| 关 键 词： | 中药化学；蔷薇红景天；多酚；响应面法 |
| Title： | Ultrasonic extraction technology optimization of polyphenols from Rhodiola rosea by response surface methodology |
| Author： | ZHAO Yan, ZHAO Tianqi, CAI Enbo, XU Yonghua, LIU Shuangli, YANG He, ZHANG Lianxue |
| Organization： | College of Chinese Medicinal Materials, Jilin Agricultural University |
| Abstract： | Objective: The paper studies extraction technique conditions of polyphenols from Rhodiola rosea. Methods: Using the response surface method (RSM), we optimize the extraction process of polyphenols from R.rosea. On the basis of single factor experiments, the ethanol concentration, ultrasonic extraction time and liquid-solid ratio are used as independent variables, polyphenols extraction rate as response value. According to the principle of center combination experiment designed with 3 factors and 5 levels of response surface analysis, interaction of each variable and its influence on the yield of polyphenols, simulation prediction model of quadratic polynomial regression equation was obtained. Results: After analyzing the significant interaction and the various factors, the optimum polyphenol extraction technology are as following: ethanol concentration 48% (volume ratio), ultrasonic extraction time 40 min, liquid-solid ratio 286 mL/g. Conclusion: Under the condition of optimum process, the polyphenols yield is 11.59%. The research model is suitable for polyphenols extraction from R.rosea, which can be used in practical production. |
| Key words： | Chinese medicine chemistry; Rhodiola rosea; polyphenols; response surface method |
| 发表期数： | 2014年12月第23期 |
| 引用格式： | 赵岩，赵天琦，蔡恩博，等. 响应面分析法优化蔷薇红景天多酚提取工艺[J]. 中国科技论文在线精品论文，2014，7（23）：2323-2330. |
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