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思虑过度状态患者静息态fMRI局部一致性重测研究

发表时间:2014-12-15  浏览量:1641  下载量:489
全部作者: 吴宏峗,齐向华
作者单位: 山东中医药大学附属医院脑病科
摘 要: 目的:探索思虑过度状态(over-anxiety condition,OAC)患者静息态功能磁共振成像(functional magnetic resonance imaging,fMRI)结果重测信度。方法:选择10名OAC患者接受静息态fMRI扫描,间隔2 d进行二次扫描,采用局部一致性(regional homogeneity,ReHo)计算2次测量结果的差异脑区和全脑类内相关系数(intraclass correlation coefficients,ICC)。结果:在AlphaSim校正、连接规则为边连接、P<0.05前提下,重测前后左颞上回ReHo值下降;在P<0.01或者连接规则为角连接前提下,不存在差异脑区。ICC=0.746为显著可信。结论:OAC患者静息态fMRI结果重测信度高,静息态fMRI是认知神经科学的重要研究手段。
关 键 词: 中医学;功能磁共振成像;静息态;重测信度;思虑过度
Title: Study on test-retest reliability of regional homogeneity of the resting-state fMRI for the patients with over-anxiety condition
Author: WU Hongyun, QI Xianghua
Organization: Department of Encephalopathy, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine
Abstract: Objective: To measure test-retest reliability of the resting-state functional magnetic resonance imaging (fMRI) for the patients with over-anxiety condition (OAC). Methods: 10 patients with OAC were arranged to accept the resting-state fMRI scan, and were conducted a second scan after 2 d interval. Regional homogeneity (ReHo) was adopted to calculate difference and the intraclass correlation coefficients (ICC) of the whole brain according to the 2 measurements. Results: Under the premise of AlphaSim correction, the connection rule being edge connection and the condition being P<0.05, ReHo value of left superior temporal gyrus reduced after the retest. When P<0.01 or the connection rule was the angle connection, there was no difference. ICC of the whole brain 0.746 meant substantial test-retest reliability. Conclusion: The good test-retest reliability in OAC patients displaying the resting-state fMRI is an important method for researching on cognitive neuroscience.
Key words: traditional Chinese medicine; functional magnetic resonance imaging; resting-state; test-retest reliability; over-anxiety
发表期数: 2014年12月第23期
引用格式: 吴宏峗,齐向华. 思虑过度状态患者静息态fMRI局部一致性重测研究[J]. 中国科技论文在线精品论文,2014,7(23):2337-2339.
 
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