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小鼠“足三里”穴区肥大细胞功能状态对针刺效应的影响

发表时间:2014-12-15  浏览量:1434  下载量:407
全部作者: 高轶,李忠正,阎丽娟,赵雪,郭义
作者单位: 天津中医药大学实验针灸学研究中心
摘 要: 目的:观察肥大细胞与针刺效应之间的关系。方法:采用昆明系小鼠胃排空率作为效应指标,观察各组小鼠在20 min行针过程中的胃排空率变化;同时,通过穴位组织切片染色,观察穴位分别注射色甘酸钠、复合物48/80,小鼠穴位处肥大细胞数及肥大细胞脱颗粒率的变化。结果:注射色甘酸钠可以明显减少穴位处肥大细胞数及肥大细胞脱颗粒率,此时针刺不能增加穴位处肥大细胞数及肥大细胞脱颗粒率;注射复合物48/80后,穴位处肥大细胞数及肥大细胞脱颗粒率均明显增多,此时针刺穴位处肥大细胞脱颗粒率现象显著提高。结论:穴位组织中的肥大细胞在针刺效应的产生过程中起重要作用,肥大细胞脱颗粒参与了针刺效应的产生过程。
关 键 词: 针灸学;足三里;肥大细胞;针刺效应;胃排空率
Title: Impact of mast cell function on acupuncture effect in mouse “Zusanli” point area
Author: GAO Yi, LI Zhongzheng, YAN Lijuan, ZHAO Xue, GUO Yi
Organization: Experimental Research Center of Acupuncture and Moxibustion, Tianjin University of Traditional Chinese Medicine
Abstract: Objective: To investigate the relationship between mast cells and acupuncture effect. Methods: Taking Kunming mice gastric emptying rate as the effect indicators, gastric emptying rate was observed in each group of mice for 20 min in the process of changing the needle row. While tissue sections stained by acupuncture, acupoint injection of cromolyn sodium, compound 48/80 respectively. The number and rate of change of degranulation of mast cells in mouse mast cells acupuncture points were observed. Results: Cromolyn sodium injection could significantly reduce the number of points at the mast cells and mast cell degranulation rate, then acupuncture could increase the number of points at the mast cells and mast cell degranulation rate. After injection of compound 48/80 point at mast cells, the number and mast cell degranulation rates were significantly increased, while the acupuncture phenomenon mast cell degranulation rate improved significantly. Conclusion: This study showed that acupuncture tissue mast cells played an important role in the production process of acupuncture effect, and the mast cell degranulation process was involved in the generation of acupuncture effect.
Key words: science of acupuncture and moxibustion; Zusanli; mast cell; acupuncture effect; gastric emptying rate
发表期数: 2014年12月第23期
引用格式: 高轶,李忠正,阎丽娟,等. 小鼠“足三里”穴区肥大细胞功能状态对针刺效应的影响[J]. 中国科技论文在线精品论文,2014,7(23):2340-2347.
 
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