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表皮葡萄球菌色氨酰-tRNA合成酶抑制剂W-23的抗菌活性研究

发表时间:2014-12-15  浏览量:1346  下载量:543
全部作者: 吴旸,毛嘉琳,瞿涤
作者单位: 复旦大学上海医学院,医学分子病毒学教育部/卫生部重点实验室
摘 要: 目的:检测色氨酰-tRNA合成酶(tryptophanyl-tRNA synthetase,WRS)抑制剂W-23对葡萄球菌的抗菌活性。方法:采用肉汤稀释法检测W-23对表皮葡萄球菌、金黄色葡萄球菌、大肠杆菌的最低抑菌浓度(minimal inhibitory concentration,MIC),并检测其与氨苄青霉素或氯霉素联用对表皮葡萄球菌的联合抗菌效果。结果:化合物W-23对葡萄球菌属的MIC为2~4 mg/L,抗菌类型属于抑菌剂,与氨苄青霉素联用对耐甲氧西林表皮葡萄球菌具有协同抗菌作用。结论:W-23对葡萄球菌抗菌活性较强,具有潜在应用价值。
关 键 词: 医学微生物;葡萄球菌;色氨酰-tRNA合成酶;抑制剂W-23
Title: Antibacterial activity of an inhibitor W-23 of Staphylococcus epidermidis tryptophanyl-tRNA synthetase
Author: WU Yang, MAO Jialin, QU Di
Organization: Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical School, Fudan University
Abstract: Objective: To investigate the antibacterial activity of W23, an inhibitor of Staphylococcus epidermidis tryptophanyl-tRNA synthetase (WRS). Methods: We determine the minimal inhibitory concentration (MIC) of W-23 to S.epidermidis, S.taphylococcus and Escherichia coli using broth dilution method and detect the effect of W-23 in combination with ampicillin or chloramphenicol on S.epidermidis growth. Results: The MIC of W-23 to Staphylococcus species is about 2-4 mg/L and it is a bacteristatic agent. Combination of W-23 and ampicillin has synergistic effect on growth of methicillin-resistent S.epidermidis. Conclusion: W-23 has potent antibacterial activity against Staphylococcus and has a potential value in new drug development.
Key words: medical microbiology; Staphylococcus; tryptophanyl-tRNA synthetase; inhibitor W-23
发表期数: 2014年12月第23期
引用格式: 吴旸,毛嘉琳,瞿涤. 表皮葡萄球菌色氨酰-tRNA合成酶抑制剂W-23的抗菌活性研究[J]. 中国科技论文在线精品论文,2014,7(23):2362-2366.
 
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