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归附痛经颗粒对寒凝血瘀证模型大鼠血液流变性的影响

发表时间:2014-12-15  浏览量:1280  下载量:529
全部作者: 于瑞红,曹蕾
作者单位: 西安交通大学医学院
摘 要: 目的:观察归附痛经颗粒对寒凝血瘀证模型大鼠血液流变性的影响。方法:制作急性寒凝血瘀证大鼠模型,用归附痛经颗粒灌胃1周,取血检测全血黏度和还原黏度、红细胞变形指数和刚性指数、红细胞压积、血浆黏度、纤维蛋白原及血沉。结果:与正常组比较,模型组全血高切、低切黏度和低切还原黏度明显升高(P<0.01),高切还原黏度、红细胞刚性指数有所升高(P<0.05);与模型组比较,0.5 g/kg和1.0 g/kg 剂量的归附痛经颗粒能降低血瘀大鼠全血高切黏度、全血低切黏度和低切还原黏度(P<0.01)。结论:归附痛经颗粒能改善寒凝血瘀证大鼠的血瘀状态。
关 键 词: 药理学;归附痛经颗粒;寒凝血瘀证;血液流变性
Title: Effects of Guifutongjing granula on hemorheology of congealing cold and blood stasis rats
Author: YU Ruihong, CAO Lei
Organization: School of Medicine, Xi’an Jiaotong University
Abstract: Objective: To observe the effects of Guifutongjing granula on hemorheology of congealing cold and blood stasis rats. Methods: We make the model of congealing cold and blood stasis in rats, and intragastric administration Guifutongjing granula for 1 week, then collect blood by abdominal aortic method and determine blood specific and reductive viscosity, erythrocyte deformation index and rigid index, hematocrit, plasma viscosity, fibrinogen and erythrocyte sedimentation rate. Results: Compared with normal group, high-shearrate blood viscosity, low-shearrate blood viscosity and low-shearrate reductive viscosity of model group increased greatly (P<0.01), high-shearrate reductive viscosity and erythrocyte rigid index increased to some degree (P<0.05). Compared with model group, 0.5 g/kg and 1.0 g/kg groups of Guifutongjing granula reduce high-shearrate blood viscosity, low-shearrate blood viscosity and low-shearrate reductive viscosity (P<0.01). Conclusion: Guifutongjing granula can improve the blood stasis state of congealing cold and blood stasis rats.
Key words: pharmacology; Guifutongjing granula; syndrome of congealing cold and blood stasis; hemorheology
发表期数: 2014年12月第23期
引用格式: 于瑞红,曹蕾. 归附痛经颗粒对寒凝血瘀证模型大鼠血液流变性的影响[J]. 中国科技论文在线精品论文,2014,7(23):2379-2382.
 
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