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维生素C与细胞重编程

发表时间:2015-06-15  浏览量:1553  下载量:731
全部作者: 高倩,于洋
作者单位: 北京大学第三医院生殖医学中心
摘 要: 维生素C(vitamin C, Vc)是一种常见的抗氧化剂,在多种生化反应中扮演着重要的角色。近期研究表明,添加Vc可以提高诱导多能干细胞(induced pluripotent stem cells,iPS)的重编程效率,其中主要原因是Vc可以在全基因组水平引起DNA的表观遗传变化,从而加速体细胞到干细胞的细胞命运转化。这里综述Vc在重编程过程中提高效率的可能分子机制,以及Vc对于iPS细胞质量改良的原因,为进一步阐明Vc对于细胞代谢和表观遗传调控的分子机制提供一定依据。
关 键 词: 医学细胞生物学;细胞重编程;综述;维生素C;诱导多能干细胞
Title: Vitamin C and cell reprogramming
Author: GAO Qian, YU Yang
Organization: Reproductive Medical Center, Peking Universiry Third Hospital
Abstract: Vitamin C (Vc) is a common kind of antioxidant, playing important roles in various biochemical reactions. Recently, the reprogramming efficiency of somatic cells to induced pluripotent stem cells (iPS) were advanced in the presence of Vc. One essential reason of that might be Vc could introduce great epigenetic changes in whole-genome scale, which accelerates the cell fate alternation from somatic cells to stem cells. In this review, we summarize the molecular mechanism that why Vc enhances the reprogramming efficiency during the iPS process and why Vc optimizes the quality of iPS cells, this review provides the basis of further clarifying the effects of Vc for cell metabolism and molecular mechanism of epigenetic regulation.
Key words: medical cell biology; reprogramming; review; vitamin C; induced pluripotent stem cells
发表期数: 2015年6月第11期
引用格式: 高倩,于洋. 维生素C与细胞重编程[J]. 中国科技论文在线精品论文,2015,8(11):1117-1121.
 
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