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薯蓣皂苷对大鼠非酒精性脂肪肝作用的初步研究

发表时间:2015-06-15  浏览量:1304  下载量:414
全部作者: 许丽娜,齐艳,尹连红,韩旭,许有威,赵艳艳,彭金咏
作者单位: 大连医科大学药学院
摘 要: 目的:初步探讨薯蓣皂苷(dioscin,Dio)对非酒精性脂肪肝(nonalcoholic fatty liver disease,NAFLD)模型大鼠的影响。方法:建立大鼠高脂饮食NAFLD模型,给予Dio治疗12周后,观察对照组、模型组及Dio给药组大鼠体重、肝指数和组织病理学改变,并对谷丙转氨酶(alanine transaminase,ALT)、谷草转氨酶(aspartate aminotransferase,AST)、总甘油三酯(total triglyceride,TG)、总胆固醇(total-cholesterol,TC)、低密度脂蛋白(low density lipoprotein cholesterol,LDL-C)、高密度脂蛋白(high density lipoprotein cholesterol,HDL-C)、瘦素(leptin)、肿瘤坏死因子-α(tumor necrosis factors α,TNF-α)和丙二醛(malondialdehyde,MDA)等生化指标的变化进行检测。结果:与模型组比较,Dio能降低高脂饮食所致大鼠体重和肝指数的增加,改善肝脏组织的脂肪变性,降低AST,ALT,TG,TC,LDL-C,瘦素,TNF-α和MDA含量,升高HDL-C含量。结论:Dio可以减轻高脂饮食诱导的大鼠肝脂肪变,有可能作为治疗NAFLD的有效药物。
关 键 词: 药理学;薯蓣皂苷;非酒精性脂肪肝;大鼠
Title: Effects of dioscin on experimental model of nonalcoholic fatty liver disease in rats
Author: XU Lina, QI Yan, YIN Lianhong, HAN Xu, XU Youwei, ZHAO Yanyan, PENG Jinyong
Organization: College of Pharmacy, Dalian Medical University
Abstract: Objective: To investigate the effects of dioscin (Dio) on nonalcholic fatty liver disease (NAFLD) rats. Methods: The high fat diet induced-NAFLD rats were used in this study. After treating with dioscin for 12 weeks, the body weight, liver index, histopathological changes were tested in Dio group as well as in the control group and the model group. Meanwhile, biochemical indices of alanine transaminase (ALT), aspartate aminotransferase (AST), total triglyceride (TG), total-cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), leptin, tumor necrosis factors α (TNF-α) and malondialdehyde (MDA) were all detected. Results: Compared with model group, Dio can decrease the body weight and liver index caused by high fat diet to improve liver steatosis. The levels of TC, TG, LDL-C, leptin, TNF-α and MDA are significantly decreased compared with model group, while the level of HDL-C is markedly elevated. Conclusion: Dio can reduce the liver steatosis induced by NAFLD in rat liver, which might be used as a new effective drug for NAFLD treatments.
Key words: pharmacology; dioscin; nonalcoholic fatty liver disease; rat
发表期数: 2015年6月第11期
引用格式: 许丽娜,齐艳,尹连红,等. 薯蓣皂苷对大鼠非酒精性脂肪肝作用的初步研究[J]. 中国科技论文在线精品论文,2015,8(11):1152-1156.
 
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