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HMGB1基因多态性与非小细胞肺癌患者铂类化疗血液学毒性的相关性研究
发表时间：2015-06-15 浏览量：1853 下载量：742
| 全部作者： | 郑艺，尹继业，刘昭前 |
| 作者单位： | 中南大学湘雅医院临床药理研究所，遗传药理学湖南省重点实验室；湖南省妇幼保健院药学部 |
| 摘 要： | 目的：探讨高迁移率族蛋白1（high mobility group box 1 protein，HMGB1）基因单核苷酸多态性（single nucleotide polymorphism，SNP）与晚期非小细胞肺癌（non-small cell lung cancer，NSCLC）患者铂类药物血液学毒性的关系。方法：使用时间飞行质谱生物芯片系统（Sequenom Mass ARRAY）对437例确诊的NSCLC患者HMGB1基因3个标签SNP位点进行分型，讨论其对铂类化疗血液学毒性反应的相关性。结果：未发现HMGB1基因3个SNP位点与铂类总血液学毒性的发生有显著性关联。进一步对各项血液学毒性进行分析时，发现HMGB1 rs1045411突变纯合基因型AA显著增加了患者发生3～4度血小板减少的风险，而rs2249825在显性模型中与3～4度血小板减少显著关联。结论：HMGB1 rs1045411和rs2249825与3～4度血小板减少显著关联，可作为分子标记物预计铂类化疗血液学毒性反应。 |
| 关 键 词： | 临床药理学；血液学毒性；单核苷酸多态性；高迁移率族蛋白1；铂类；肺癌 |
| Title： | Association between HMGB1 genetic variations and hematologic toxicities of platinum-based chemotherapy in NSCLC patients |
| Author： | ZHENG Yi, YIN Jiye, LIU Zhaoqian |
| Organization： | Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology, Xiangya Hospital, Central South University; Department of Pharmacy, Hunan Provincial Maternal and Child Health Care Hospital |
| Abstract： | Objective: Aimed at discussing the relationship between single nucleotide polymorphism (SNP) in high mobility group box 1 protein (HMGB1) and hematologic toxicity of platinum-based therapy in non-small cell lung cancer (NSCLC) patients. Methods: Sequenom Mass ARRAY was used to detect 3 tagged SNPs in HMGB1 in 437 NSCLC patients as well as their effect on the hematologic toxicity of the platinum-based chemotherapy. Results: No significant correlation is discovered between 3 SNPs in HMGB1 gene with total platimum-based hematologic toxicities. Further analysis of hematologic toxicities revealed that HMGB1 rs1045411 homozygous mutations AA genotype significantly increases the risk of reduction of 3-4 grades thrombocytopenia while rs2249825 is apparently related with the reduction of 3-4 grades thrombocytopenia in dominant model. Conclusion: Polymorphisms of rs1045411 and rs2249825 in HMGB1 are significantly associated with the reduction of 3-4 grades thrombocytopenia, which can be used as molecular marker to predict hematologic toxicity of platinum-based chemotherapy. |
| Key words： | clinical pharmacology; hematologic toxicities; single nucleotide polymorphism; high mobility group box 1 protein; platinum; lung cancer |
| 发表期数： | 2015年6月第11期 |
| 引用格式： | 郑艺，尹继业，刘昭前. HMGB1基因多态性与非小细胞肺癌患者铂类化疗血液学毒性的相关性研究[J]. 中国科技论文在线精品论文，2015，8（11）：1157-1163. |
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