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基于辐射传输方程的小动物扩散荧光层析成像方法

发表时间:2016-03-15  浏览量:1744  下载量:534
全部作者: 张燕,李娇,赵会娟,张丽敏,高峰
作者单位: 天津大学精密仪器与光电子工程学院;天津大学,天津市生物医学检测技术与仪器重点实验室
摘 要: 扩散荧光层析成像(diffuse florescence tomography,DFT)作为一种能够定量提供特异性分子探针空间分部信息的高灵敏度光学分子成像工具,被逐渐应用于小动物疾病模型体内生化过程的在体跟踪和检测。DFT中,正向模型一般用辐射传输方程(radiative transfer equation,RTE)的P1近似即扩散方程(diffuse equation,DE)来实现。而对于组织内部有空腔区、近光源区的小动物成像情况,基于RTE的DFT方法更合适。研究提出一个基于RTE的稳态DFT方法,联合离散立体角元法和有限差分法,采用自然边界条件和准直光源模型,获取二维稳态RTE的数值解。利用蒙特卡罗产生的正向数据模拟验证此方案的可行性,并证明其相对于DE提高了空间分辨率和重建质量。
关 键 词: 生物医学工程学;扩散荧光层析成像;辐射传输方程;离散立体角元;自然边界条件;小动物成像
Title: Diffuse fluorescence tomography based on radiative transfer equation for small-animal imaging
Author: ZHANG Yan, LI Jiao, ZHAO Huijuan, ZHANG Limin, GAO Feng
Organization: School of Precision Instrument and Opto-Electronics Engineering, Tianjin University; Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments, Tianjin University
Abstract: Diffuse florescence tomography (DFT) as a high-sensitivity optical molecular imaging tool, can be applied to in vivo visualize interior cellular and molecular events for small-animal disease model through quantitatively recovering biodistributions of specific molecular probes. In DFT, the radiative transfer equation (RTE) and its approximation P1, such as the diffuse equation (DE), have been used as the forward models. The RTE-based DFT methodology is more suitable for biological tissue having void-like regions and the near-source area as in the situations of small animal imaging. We present a RTE-based scheme for the steady state DFT, which combines the discrete solid angle method and the finite difference method to obtain numerical solutions of the 2D steady RTE, with the natural boundary condition and collimating light source model. The approach is validated using the forward data from the Monte Carlo simulation for its better performances in the spatial resolution and reconstruction fidelity compared to the DE-based scheme.
Key words: biomedical engineering; diffuse fluorescence tomography; radiative transfer equation; discrete solid angle; natural boundary condition; small-animal imaging
发表期数: 2016年3月第5期
引用格式: 张燕,李娇,赵会娟,等. 基于辐射传输方程的小动物扩散荧光层析成像方法[J]. 中国科技论文在线精品论文,2016,9(5):476-483.
 
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