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离子交换法制备磷酸钙微球及其表征
发表时间：2016-03-15 浏览量：1849 下载量：683
| 全部作者： | 夏晓钰，顾丽红，杨华，宋学英，顾微 |
| 作者单位： | 首都医科大学化学生物学与药学院；首都医科大学医学实验与测试中心 |
| 摘 要： | 磷酸钙在各领域均发挥着至关重要的作用，且其有多种制备方法。本研究主要目的为通过离子交换法，使用碳酸钙制备磷酸钙，并通过各种手段证实这一过程。首先以淀粉为模板仿生合成碳酸钙微球，然后在常温常压下通过离子交换反应将其转换为磷酸钙微球。采用透射电子显微镜（transmission electron microscopy，TEM）、傅里叶变换红外光谱仪（Fourier transform infrared spectroscopy，FT-IR）、X射线衍射仪（X-ray diffraction，XRD）、激光纳米粒度仪等对所制备的磷酸钙微球进行表征。生成的物质粒径发生明显变化，且FT-IR图和XRD图谱的结果均产生了前后变化，碳酸钙的特征峰消失，且显示出磷酸钙的特征峰。各项结果均表明，通过离子交换反应可成功将碳酸钙转换成为磷酸钙。 |
| 关 键 词： | 药剂学；仿生合成；碳酸钙；磷酸钙；模板；离子交换反应 |
| Title： | Preparation and characterization of calcium phosphate microspheres by ion exchange method |
| Author： | XIA Xiaoyu, GU Lihong, YANG Hua, SONG Xueying, GU Wei |
| Organization： | School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University; Medical Experiment and Test Center, Capital Medical University |
| Abstract： | Calcium phosphate plays an important role in various fields, and it has a variety of preparation methods. The main purpose of this paper is to use the ion exchange method to prepare calcium phosphate by using calcium carbonate, and to confirm the process by various means. Firstly, the calcium carbonate microspheres were synthesized by using starch as the template, and then were converted to calcium phosphate microspheres by ion exchange reaction at room temperature and standard pressure. The calcium phosphate microspheres were characterized by transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and laser nano particle size analyzer. The particle size of the particles was obviously changed, and the results of the FT-IR spectrum and XRD map revealed the changes before and after, the characteristic peak of calcium carbonate disappeared, and the characteristic peak of calcium phosphate displayed. All the results showed that the calcium carbonate could be converted into calcium phosphate by ion exchange reaction. |
| Key words： | pharmaceutics; biomimetic preparation; calcium carbonate; calcium phosphate; template; ion exchange reaction |
| 发表期数： | 2016年3月第5期 |
| 引用格式： | 夏晓钰，顾丽红，杨华，等. 离子交换法制备磷酸钙微球及其表征[J]. 中国科技论文在线精品论文，2016，9（5）：518-521. |
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