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孕期镉暴露对子代发育及其学习记忆能力的影响

发表时间:2016-06-15  浏览量:2026  下载量:660
全部作者: 赵奇红,刘起飞,胡安拉,李李,陶芳标
作者单位: 安徽医科大学公共卫生学院
摘 要: 目的:研究孕期镉暴露对小鼠子代生长发育和学习记忆能力的影响。方法:通过在孕鼠饮水中添加10 mg/L CdCl2的方法建立镉暴露动物模型,镉暴露时长从孕0 d起至生产日结束。根据孕期镉暴露将子代分成2组,分别为正常对照组和镉暴露组。子代小鼠出生5周和7周后进行Morris水迷宫实验,观察各组实验动物学习记忆能力的改变。结果:仔鼠出生时体重、身长和尾长都没有差别,但是分娩3周后仔鼠中镉暴露组的体重低于正常对照组;分娩5周、7周后仔鼠中全程镉暴露组逃避潜伏期高于正常对照组;分娩7周后仔鼠中镉暴露组平台搜寻时间低于正常对照组。结论:孕期镉暴露对子代的生长发育及空间学习和记忆能力存在影响。
关 键 词: 儿少卫生学;孕期;低剂量镉暴露;子代发育;学习记忆能力
Title: Influence of cadmium exposure during pregnancy on offspings’ growth and learning and memorizing functions
Author: ZHAO Qihong, LIU Qifei, HU Anla, LI Li, TAO Fangbiao
Organization: School of Public Health, Anhui Medical University
Abstract: Objective: The purpose of this study is to elucidate the influence of cadmium exposure during pregnancy on offsprings’ growth and learning and memorizing functions. Methods: We established the animal model of cadmium exposure by adding 10 mg/L CdCl2 to the drinking water for pregnant mice from 0 d of the pregnancy to the day they gave birth. We divided the offspring into 2 groups: normal control group and cadmium exposure group. We conducted the experiment of Morris water maze at their 5 and 7 week-old and observed their changes in the learning and memorizing functions. Results: The body weight, body length and tail length of offspring newborn in cadmium exposure group were the same as that in normal control group, but the body weight of 3 week-old offspring was lower than that in normal control group. The escape latency of 5 and 7 week-old offspring in cadmium exposure group was longer than that in normal control group. The platform searching time of 7 week-old offspring in cadmium exposure group was shorter than that in normal control group. Conclusion: Cadmium exposure during pregnancy has certain certion influence on offsprings’ growth and learning and memorizing functions.
Key words: children and adolescents hygiene; pregnancy; low-dose cadmium exposure; offsping development; learning and memorizing functions
发表期数: 2016年6月第11期
引用格式: 赵奇红,刘起飞,胡安拉,等. 孕期镉暴露对子代发育及其学习记忆能力的影响[J]. 中国科技论文在线精品论文,2016,9(11):1174-1178.
 
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