您的位置:首页  > 论文页面

药材川芎化学成分研究

发表时间:2016-06-15  浏览量:1652  下载量:582
全部作者: 房鑫,马强,冯怡,梁爽
作者单位: 上海中医药大学中药现代制剂技术教育部工程研究中心
摘 要: 目的:对药材川芎的化学成分进行研究。方法:采用硅胶柱色谱、凝胶柱色谱、中压制备液相色谱(middle performance liquid chromatography,MPLC)、高压制备液相色谱(high performance liquid chromatography,HPLC)等方法进行分离纯化,通过核磁共振(nuclear magnetic resonance,NMR)、质谱(mass spectrometry,MS)等波谱手段对化合物进行结构鉴定。结果:从川芎石油醚部位中分离了19个化合物,分别为3a-羟基-6-羰基-新蛇床酞内酯(1)、洋川芎内酯A(2)、藁本内酯(3)、Z-丁烯基苯酞(4)、丁苯酞(5)、洋川芎内酯 I(6)、洋川芎内酯 H(7)、洋川芎内酯 J(8)、洋川芎内酯 N(9)、3\',6\',8\',3a-二聚藁本内酯(10)、川芎内酯 A(11)、欧当归内酯 A(12)、Z-3\',8\',3\'a-7\'a-四氢-6,3\',7\',7\'a-二聚藁本内酯-8\'-酮(13)、tokinolide B(14)、exo-Z,Z \'-3a.7\'a,7.3\'a-二聚藁本内酯(15)、Z-6,8\',7,3\'-二聚藁本内酯(16)、5-羟甲基糠醛(17)、咖啡酸甲酯(18)、阿魏酸(19)。结论:19个化合物中包括9个苯酞类化合物(1~9), 7个二聚苯酞类化合物(10~16),其中化合物1为新化合物。
关 键 词: 中药化学;川芎;化学成分;苯酞类化合物;二聚苯酞类化合物
Title: Chemical constituents of Chuanxiong Rhizoma
Author: FANG Xin, MA Qiang, FENG Yi, LIANG Shuang
Organization: Engineering Research Center of Modern Preparation Technology of TCM, Ministry of Education, Shanghai University of Traditional Chinese Medicine
Abstract: Objective: To isolate and identify the chemical constituents of Chuanxiong Rhizoma. Methods: Compounds were isolated by various kinds of column chromatographies on silica gel, Sephadex LH-20, middle performance liquid chromatography (MPLC) and high performance liquid chromatography (HPLC), and their structures were elucidated by the physicochemical properties and spectral analysis including nuclear magnetic resonance (NMR) and mass spectrometry (MS). Results: Nineteen chemical constituents were obtained and identified as 3a-hydroxy-6-carbonyl-neocnidilide (1), senkyunolide A (2), ligustilide (3), Z-butylidenephthalide (4), butylphthalide (5), senkyunolide I (6), senkyunolide H (7), senkyunolide J (8), senkyunolide N (9), 3',6',8',3a-diligustilide (10), Chuanxiongnolide A (11), levistolide A (12), Z-3',8',3'a-7'a-tetrahydro-6,3',7',7'a-diligustilide-8'-one (13), tokinolide B (14), exo-Z,Z '-3a.7'a,7.3'a- diligustilide (15), Z-6,8',7,3'-diligustilide (16), 5-(hydroxymethyl)-2-furaldehyde (17), methyl caffeate (18), fumalic acid (19). Conclusion: Among the isolated 19 compounds, there are 9 phthalides (1-9), 7 dimerphthalides (10-16), and compound (1) is a new phthalide.
Key words: chemistry of Chinese medicine; Chuanxiong Rhizoma; chemical constituents; phthalide; dimerphthalide
发表期数: 2016年6月第11期
引用格式: 房鑫,马强,冯怡,等. 药材川芎化学成分研究[J]. 中国科技论文在线精品论文,2016,9(11):1090-1096.
 
0 评论数 0
暂无评论
友情链接