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3,4-二氢-1,8-萘啶酮类化合物的高效合成
发表时间:2016-07-15 浏览量:6847 下载量:2496
全部作者: | 周俊,凌鹏翔,李博,史炳锋 |
作者单位: | 浙江大学化学系 |
摘 要: | 3,4-二氢-1,8-萘啶酮衍生物是重要的杂环化合物,具有独特的生物化学性质。研究报道了通过铑催化吡啶C3碳氢键选择性烯基化的方法,制备了一些3-烯基-2-氨基吡啶化合物。并从3-烯基-2-氨基吡啶化合物出发,经过催化加氢、分子内环化两步反应,合成了一系列3,4-二氢-1,8-萘啶酮衍生物。反应条件温和,操作简单。 |
关 键 词: | 有机化学;3,4-二氢-1,8-萘啶酮;加氢;环化 |
Title: | Expeditious synthesis of 3,4-dihydro-1,8-naphthyridin-2(1H)-one derivatives |
Author: | ZHOU Jun, LING Pengxiang, LI Bo, SHI Bingfeng |
Organization: | Department of Chemistry, Zhejiang University |
Abstract: | 3,4-dihydro-1,8-naphthyridine derivatives are important heterocyclic compounds which have special biological and chemical properties. We reported herein the synthesis of 3-alkenyl-2-aminopyridines via Rh-catalyzed C—H olefination of the C3 position of pyridines. Subsequently, a series of 3,4-dihydro-1,8-naphthyridin-2(1H)-ones have been prepared from 3-alkeny pyridines in one pot via two steps, including catalytic hydrogenation and intramolecular cyclization. This protocol proceeded under mild reaction conditions and was operationally simple. |
Key words: | organic chemistry; 3,4-dihydro-1,8-naphthyridin-2(1H)-one; hydrogenation; cyclization |
发表期数: | 2016年7月第13期 |
引用格式: | 周俊,凌鹏翔,李博,等. 3,4-二氢-1,8-萘啶酮类化合物的高效合成[J]. 中国科技论文在线精品论文,2016,9(13):1293-1298. |
用户ly1504:合成方法简单易懂,实验条件易达到