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n-HA/PA66对损伤胸腰椎骨生物力学属性的恢复效果研究

发表时间:2016-08-15  浏览量:1206  下载量:423
全部作者: 沈 伟,林 峰,蒋雪梅
作者单位: 重庆大学生物工程学院,生物流变科学与技术教育部重点实验室;北京大学工学院
摘 要: 目的:研究经伤椎椎弓根植入纳米羟基磷石灰/聚酰胺(nanohydroxyapatite/polyamide-66,n-HA/PA66)复合人工骨粒对损伤胸腰椎体的生物力学属性的恢复效果,探究其临床应用价值。方法:选取10具人体T12-L2节段脊柱标本,将其随机平分为两组:自体松质骨组(cancellous bone,CB)与n-HA/PA66(NHP)组。椎体损伤后经椎弓根植入上述填充物,并自主设计夹具,利用万能试验机在轴向、前屈、后伸及侧弯四个方向测试椎体功能段T12-L2的刚度与椎体L1的应变。结果:与CB组相比,NHP组在轴向、前屈及侧弯方向上重建椎体刚度显著增加(P<0.05),椎体L1应变显著降低(P<0.05),表明NHP能较好地恢复损伤椎体的生物力学属性。结论:n-HA/PA66骨替代物比松质骨能更好地恢复损伤胸腰椎骨的生物力学性质,具有一定的临床应用价值。
关 键 词: 生物力学;n-HA/PA66;自体骨移植;胸腰椎骨折
Title: Effects of n-HA/PA66 on the recovery of biomechanical properties for injured thoracolumbar vertebrae
Author: SHEN Wei, LIN Feng, JIANG Xuemei
Organization: Key Laboratory of Biorheological Science and Technology, Bioengineering College,Chongqing University; College of Engineering, Peking University
Abstract: Objective: In this paper, the effects of nanohydroxyapatite/polyamide-66 (n-HA/PA66) as the transpedicular graft material in biomechanical properties in treating thoracolumbar fractures was addressed, and we investigated the value of clinic application. Methods: Ten T12-L2 vertebrae were harvested from human cadavers and randomly devided into two groups: cancellous bone (CB) and n-HA/PA66 (NHP). We implanted the graft material after vertebral injure, measured the stiffness of functional units (T12-L2) and strain of L1 by using of self-designed fixture and material testing machine. Results: Our results show that, compared to CB, the stiffness of T12-L2 was significantly increased in NHP (P<0.05), and the strain of L1 was significantly decreased (P<0.05), demonstrating that NHP can better recover the biomechanical properties of injured vertebra. Conlusion: n-HA/PA66 is better than cancellous bone in mechanics for reconstruction of thoracolumber fractures, which has certain clinical value. However, n-HA/PA66 grafts alone can not recover the biomechanical properties of injured vertebra to that of intact vertebrae, so further studies are needed.
Key words: biomechanics; n-HA/PA66; autogenous bone graft; thoracolumbar fracture
发表期数: 2016年8月第15期
引用格式: 沈 伟,林 峰,蒋雪梅. n-HA/PA66对损伤胸腰椎骨生物力学属性的恢复效果研究[J]. 中国科技论文在线精品论文,2016,9(15):1587-1592.
 
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