您的位置:首页  > 论文页面

抗中性粒细胞胞质抗体相关血管炎动物模型

发表时间:2016-09-15  浏览量:1398  下载量:667
全部作者: 黄 明,李卫东
作者单位: 北京大学医学部基础医学院
摘 要: 抗中性粒细胞胞质抗体(antineutrophil cytoplasmic autoantibody,ANCA)相关血管炎(ANCA associated vasculitis,AAV)是一种严重的全身性疾病,能够影响关节、肺、肾脏、皮肤及其他组织,致死率约80%. ANCA在血管炎中的靶标抗原是蛋白酶3(proteinase 3,PR3)和髓过氧化物酶(myeloperoxidase,MPO),而ANCA相关血管炎模型主要以MPO抗体免疫相关的模型(MPO-ANCA)为主,还包括有PR3(PR3-AAV)及溶酶体膜蛋白2免疫血管炎模型(LAMP-2-AAV)。通过诱导MPO异常免疫应答,小鼠及大鼠模型均能产生类似于人类MPO-ANCA 血管炎的病理状态,这种病原抗体的消极转移为急性血管损伤分子机制的研究提供了一种有力的工具。由于动物模型与人类疾病的相关性,因此利用这些模型可对人类抗ANCA相关血管炎的免疫发病机理进行研究,进而有可能发现新的治疗靶点。本文着重讨论近年来ANCA相关血管炎动物模型的种类及建立方法,为深入研究其发病过程提供依据。
关 键 词: 基础药理学;抗中性粒细胞胞质抗体;综述;血管炎;动物模型;髓过氧化物酶
Title: Animal models of antineutrophil cytoplasmic autoantibody associated vasculitis
Author: HUANG Ming, LI Weidong
Organization: School of Basic Medical Science, Peking University Health Science Center
Abstract: Antineutrophil cytoplasmic autoantibody (ANCA) associated vasculitis (AAV) is a severe systemic disease affecting joints, lung, kidney, skin and other tissues, whose lethality is approximately 80%. Two main targets in ANCA vasculitis are proteinase 3 (PR3) and myeloperoxidase (MPO) respectively. Evidence from studies has shown that animal models of MPO-ANCA disease occupy a dominant part in AAV, which also includes PR3-AAV and LAMP-2-AAV. The pathological process of MPO-AAV rodent models is similar to that of human by inducing MPO associated immune response. As a consequence, investigation using these animal models has provided approaches to mechanisms of human AAV and novel therapeutic targets. The present review will focus on the variety and establishment methods of AAV animal models to investigate the pathological process of AAV, and to provide a basis for further study of the pathogenesis of the disease.
Key words: basis pharmacology; antineutrophil cytoplasmic autoantibody; review; vasculitis; animal models; myeloperoxidase
发表期数: 2016年9月第17期
引用格式: 黄 明,李卫东. 抗中性粒细胞胞质抗体相关血管炎动物模型[J]. 中国科技论文在线精品论文,2016,9(17):1733-1738.
 
1 评论数 0
暂无评论
友情链接