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新型氮掺杂型碳量子点的制备及其在生物成像中的应用

发表时间:2016-09-15  浏览量:1310  下载量:569
全部作者: 张苗苗,房正邹,赵雪纷,牛媛媛,娄嘉明,夏 圣,杜凤移
作者单位: 江苏大学医学院
摘 要: 碳量子点(carbon dots,CDs)是一种新兴的无机准零维碳纳米材料,因其优异的荧光性能和生物相容性而被应用于生物医学领域。以透明质酸和甘氨酸为前驱物,通过水热法一步制备生物亲和型氮掺杂碳量子点(nitrogen-doped carbon dots,NCDs)。通过透射电子显微镜(transmission electron microscopy,TEM)、傅里叶变换红外光谱(Fourier transform infrared spectroscopy,FTIR)、荧光光谱、射线衍射(X-ray diffraction,XRD)光谱对其进行表征研究发现,NCDs具有较为均一的粒径分布(约为3.2 nm)、丰富的亲水表面基团、稳定的荧光性能和较高的荧光量子产率(12%)。生物实验结果表明,NCDs具有较好的生物相容性和血液相容性,可快速进入细胞内部并成功应用于肿瘤细胞的荧光成像。
关 键 词: 生物医学工程学;氮掺杂碳量子点;水热法;透明质酸;荧光成像
Title: Preparetion of novel nitrogen-doped carbon dots for bioimaging
Author: ZHANG Miaomiao, FANG Zhengzou, ZHAO Xuefen, NIU Yuanyuan, LOU Jiaming, XIA Sheng, DU Fengyi
Organization: School of Medicine, Jiangsu Unversity, Zhenjiang
Abstract: Carbon dots (CDs) are new inorganic quasi-zero-dimensional carbon nanomaterials, and can be applied in biomedical area due to their good biocompability and unique fluorescence properties. Nitrogen-doped carbon dots (NCDs) are prepared by hydrothermal process using hyaluronic acid and glycine as precursors. NCDs have the property of uniform size distribution (around 3.2 nm), hydrophilic surface groups, stable fluorescence and high fluorescence quantum yield (12%) by transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FITR), fluorescence spectra, X-ray diffraction (XRD) spectrum. Also, NCDs have the characteristic of favorable biocompability, hemocompatibility and uptake by cancer cells, which can be applied in fluorescence imaging of tumor cells.
Key words: biomedical engineering; nitrogen-doped carbon dots; hydrothermal process; hyaluronic acid; fluorescence imaging
发表期数: 2016年9月第17期
引用格式: 张苗苗,房正邹,赵雪纷,等. 新型氮掺杂型碳量子点的制备及其在生物成像中的应用[J]. 中国科技论文在线精品论文,2016,9(17):1753-1758.
 
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