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MAOA基因型影响健康男性青少年抑制控制神经机制

发表时间:2016-09-15  浏览量:1502  下载量:470
全部作者: 马 任,张积标,姚树桥
作者单位: 中南大学湘雅二医院医学心理研究所;江汉大学教育学院
摘 要: 单胺氧化酶A(monoamine oxidase A,MAOA)基因一直有“战斗基因”之称,因为它和攻击有着密切关系,但是其中的神经机制尚不清楚。已有研究表明反应抑制在攻击行为发生机制中的重要作用,这里试图从反应抑制过程中大脑激活的特点入手,探究MAOA基因型影响攻击易感性的神经生物学机制。采用攻击问卷评估所有被试的攻击水平,同时收集其在进行GoStop任务时的功能性磁共振扫描图像(functional magnetic resonance imaging,fMRI)。结果表明,MAOA低表达基因型(MAOA-L)被试攻击水平显著高于MAOA高表达基因型(MAOA-H)被试。fMRI结果表明,两组的大脑激活区域相似,主要集中在前额叶区域、前扣带回、前辅助运动区、顶上/下小叶,并且MAOA-L组被试在右侧楔前叶处的大脑激活显著低于MAOA-H组。同时,右侧楔前叶处的大脑激活与攻击分数显著负相关。根据本研究结果,认为楔前叶在抑制控制脑网络中起重要作用,而偏低的右侧楔前叶激活可能是攻击行为遗传易感性的中间表型。
关 键 词: 医学心理学;单胺氧化酶A基因;攻击;抑制控制;功能性核磁共振图像;中间表型
Title: Neurophysiological mechanisms of inhibitory control in healthy male adolescents modulated by MAOA genotype
Author: MA Ren, ZHANG Jibiao, YAO Shuqiao
Organization: Medical Psychological Institute, The Second Xiangya Hospital of Central South University; School of Education, Jianghan University
Abstract: A functional polymorphism in the promoter region of monoamine oxidase A (MAOA), the gene that encodes MAO, has long been associated with aggression. Previous studies suggested that impaired response inhibition might be associated with pathological aggression, though little is known about how this process relates to the purported MAOA-aggression link. Here, we examined how MAOA genotype influences neural correlates of response inhibition in 78 healthy male adolescents using a GoStop task. At the same time, the functional magnetic resonance imaging (fMRI) were collected during the GoStop task. The results showed that subjects with low-expressing alleles (MAOA-L group) showed less activation in the precuneus during response inhibition and higher levels of aggression than subjects with high-expressing alleles (MAOA-H group). And neural response during response inhibition was most prominent in the prefrontal areas, anterior cingutate, pre-supplementary motor area, and superior/inferior parietal lobule. In addition, aggression scores correlated inversely with fMRI signals in the precuneus across both groups. Consequently, we conclude that the anterior lobe of the wedge plays an important role in the control of the brain network, and altered precuneus activation may be an intermediate phenotype determining neurogenetic susceptibility to aggression.
Key words: medical psychology; monoamine oxidase A; aggression; inhibitory control; functional magnetic resonance imaging; intermediate phenotypes
发表期数: 2016年9月第17期
引用格式: 马 任,张积标,姚树桥. MAOA基因型影响健康男性青少年抑制控制神经机制[J]. 中国科技论文在线精品论文,2016,9(17):1759-1769.
 
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