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肝素/葡聚糖复合多糖基生物水凝胶的制备及性能研究

发表时间:2016-09-30  浏览量:1377  下载量:651
全部作者: 聂井君,徐福建,李杨
作者单位: 北京化工大学材料科学与工程学院
摘 要: 结合肝素与葡聚糖两种多糖的优点,通过分别对多糖骨架的改性构建出带有酰肼键的肝素与具有碳氧双键的葡聚糖。然后通过席夫碱缩合反应将两种多糖骨架交联制备出三维网络结构的负电性水凝胶。通过凝胶化的研究和性能测试,验证水凝胶的稳定性。通过亚甲基蓝药物模型检测药物被动释放效率,证实这种新型多糖基生物水凝胶具有良好的载药能力及药物稳定性,适合作为药物的载体。
关 键 词: 高分子材料学;水凝胶;肝素;葡聚糖;药物载体
Title: Preparation of heparin-dextran based hydrogel
Author: NIE Jingjun, XU Fujian, LI Yang
Organization: College of Materials Science and Engineering, Beijing University of Chemical Technology
Abstract: Heparin and Dextran are natural polysaccharides’s exhibiting excellent bio-activates. By the chemical modifications of these polysaccharides’ backbones, hydrazide and aldehyde groups were introduced to Heparin and Dextran respectively. Then, a kind of negatively charged three dimensional networking hydrogel was prepared via Schiff-base reaction of these two modified polysaccharides. The properties of resulting hydrogels were well characterized and showed efficient stability. Subsequently, methylene blue was used as a drug model to evaluate the release rate. The release profile indicated superb stability as well as loading efficiency, which proved that such hydrogel is a suitable candidate as drug delivery vectors.
Key words: Hydrogel;Heparin;Dextran;Drug delivery vectors
发表期数: 2016年9月第18期
引用格式: 聂井君,徐福建,李杨. 肝素/葡聚糖复合多糖基生物水凝胶的制备及性能研究[J]. 中国科技论文在线精品论文,2016,9(18):1834-1839.
 
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