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抗逆转录病毒宿主因子抑制逆转录转座子LINE-1的研究

发表时间:2017-02-16  浏览量:1508  下载量:362
全部作者: 马艳杰,李晓宇
作者单位: 中国医学科学院医药生物技术研究所
摘 要: 长散布重复序列1(long interspersed nuclear element 1,LINE-1)是非长末端重复序列逆转录转座子(non-LTR retrotransposon),它的转座会引起宿主细胞DNA的变异和重排,导致癌症等各种严重的基因疾病。抗病毒宿主因子是一类具宿主自身编码的具有抗逆转录病毒功能的蛋白,是人体细胞天然免疫的重要组成部分。由于LINE-1与逆转录病毒的复制模式具有一定的相似性,所以本文探索了抗HIV-1宿主因子APOBEC3G、MOV10和SAMHD1 对LINE-1转座的抑制作用。这一工作不仅可以促进解析细胞内源性基因转座调控这一重要生命科学问题,而且为基因疾病的预防和治疗提供借鉴。
关 键 词: 微生物学;长散布重复序列1;宿主因子;APOBEC3G;MOV10;SAMHD1
Title: Studies of anti-retroviral host factors inhibit retrotransposon LINE-1
Author: MA Yanjie, LI Xiaoyu
Organization: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences
Abstract: Long interspersed nuclear element 1 (LINE-1) belongs to autonomous non-LTR retrotransposons. The replication of LINE-1 frequently causes insertion and rearrangement of host genomic DNA leading to human genetic disease. Antiviral host factors are antiviral proteins encoded by host cell iteslf belonging to innate immunity system. For the replication process of the retrotransposon is similar to that of the retrovirus, we tested the ability of the anti-HIV-1 host factor APOBEC3G, MOV10 and SAMHD1 in controlling LINE-1 mobility. The goal of the work is to explore the mechanism of the anti-retroviral host mediated restriction of LINE-1 retrotransposition, and potential application in prevention and therapeutics of related genetic diseases.
Key words: microbiology; long interspersed nuclear element 1; host factors; APOBEC3G; MOV10; SAMHD1
发表期数: 2017年2月第3期
引用格式: 马艳杰,李晓宇. 抗逆转录病毒宿主因子抑制逆转录转座子LINE-1的研究[J]. 中国科技论文在线精品论文,2017,10(3):258-264.
 
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