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髓内星形胶质瘤患者预后相关因素分析

发表时间:2017-03-15  浏览量:1152  下载量:366
全部作者: 杨利,邹莹洁,黄湘艳,谭利明
作者单位: 中南大学湘雅二医院神经内科
摘 要: 目的:研究影响髓内星形胶质瘤患者预后的相关因素,为其治疗和预后评估提供帮助。方法:收集湘雅二医院、湘雅医院、Duke医院、Sapienza医院、Pennsylvania医院髓内星形胶质瘤患者共98例作为原始数据;以“astrocytoma and spinal or spine, spinal cord and tumor, or their variations”作为关键词,在PubMed数据库进行检索,最后纳入353例患者作为检索数据;统计患者的人口统计学数据、临床症状、肿瘤特性、治疗方案及随访预后。采用SPSS 17.0统计软件进行分析,P<0.05被认为差异具有统计学意义。结果:在原始数据分析中,无进展生存期(progress free survival,PFS)的多因素分析显示独立预后相关因素为世界卫生组织(World Health Organization,WHO)等级[风险比(hazard ratio,HR):0.124~0.482],总生存期(overall survival,OS)的多因素分析显示独立预后相关因素为WHO等级(HR:0.003~0.162)。在综合数据(原始数据+检索数据)分析中,PFS的多因素分析显示独立预后相关因素包括WHO等级(HR:0.297~0.656)、手术切除程度(全切/部分切除)(HR:0.153~0.504),OS的多因素分析显示独立预后相关因素包括年龄(HR:1.007~1.026)、术前治疗(HR:3.130~8.413)、WHO等级(HR:0.083~0.216)、手术切除程度(全切/部分切除)(HR:0.312~0.765)。结论:WHO等级、手术切除程度(全切/部分切除)是PFS的独立预后相关因素,WHO等级、手术切除程度(全切/部分切除)、年龄、术前治疗是OS的独立预后相关因素。
关 键 词: 神经病学;脊髓;星形胶质瘤;WHO等级;手术切除;预后
Title: Prognostic factors analysis of patients with spinal astrocytomas
Author: YANG Li, ZOU Yingjie, HUANG Xiangyan, TAN Liming
Organization: Department of Neurology, The Second Xiangya Hospital of Central South University
Abstract: Objective: To study the prognostic factors of patients with spinal astrocytomas, and to provide help for the treatment and prognosis evaluation. Methods: 98 patients from The Second Xiangya Hospital, Xiangya Hospital, Duke University Hospital, Hospital of the Sapienza University of Rome, and Hospital of the University of Pennsylvania were used as primary cohort. PubMed database was searched. Keywords included a combination of “astrocytoma” and “spinal” or “spine”, “spinal cord” and “tumor” as well as their variations. 353 patients were finally included. Patients’ demographics, clinical symptoms, tumor characteristics, treatment, and prognosis were retrospectively reviewed. All statistical analysis were performed with SPSS 17.0, results were considered to achieve statistical significance if P<0.05. Results: Primary cohort (n=98): Multivariate analysis demonstrated that World Health Organization (WHO) grade was a significant prognostic factor of both progress free survival (PFS) [hazard ratio (HR): 0.124-0.482] and overall survival (OS) (HR: 0.003-0.162). Integrated analysis of the combined cohort (n=451): Multivariate analysis demonstrated that WHO grade (HR: 0.297-0.656) and extent of surgical resection (HR: 0.153-0.504) were significant prognostic factor of PFS; multivariate analysis demonstrated that age (HR: 1.007-1.026), prior treatment (HR: 3.130-8.413), WHO grade (HR: 0.083-0.216), and extent of surgical resection (HR: 0.312-0.765) were significant prognostic factors of OS. Conclusion: WHO grade and extent of surgical resection were significant prognostic factors of PFS; WHO grade, extent of surgical resection, age and prior treatment were significant prognostic factors of OS.
Key words: neurology; spinal cord; astrocytoma; WHO grade; surgical resection; prognosis
发表期数: 2017年3月第5期
引用格式: 杨利,邹莹洁,黄湘艳,等. 髓内星形胶质瘤患者预后相关因素分析[J]. 中国科技论文在线精品论文,2017,10(5):477-487.
 
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