您的位置:首页  > 论文页面

TCRP1及其调控因子c-myc在舌癌及肺癌中的表达

发表时间:2017-03-15  浏览量:1088  下载量:193
全部作者: 贾小婷,郑国沛,贺智敏
作者单位: 广州医科大学附属肿瘤医院肿瘤研究所
摘 要: 目的:探讨舌癌耐药相关蛋白1(tongue cancer-resistant protein 1,TCRP1)及其表达调控因子c-myc在舌癌及肺癌中的表达与临床意义。方法:将80例舌癌组织及90例肺癌组织制作成组织芯片,免疫组化检测TCRP1及c-myc的表达量,Kaplan-Meier方法制作生存曲线,分析TCRP1及c-myc的表达量与患者预后的相关性。结果:在48例高表达c-myc的舌癌组织中有42例高表达TCRP1,在32例低表达c-myc的舌癌组织中有12例高表达TCRP1. 生存曲线分析发现TCRP1表达量高或/且c-myc表达量高,舌癌患者预后差。在38例c-myc低表达的肺癌组织中有92.0%的组织也呈现TCRP1低表达,在52例c-myc高表达的肺癌组织中有86.7%的组织也呈现TCRP1高表达。生存曲线分析发现TCRP1表达量高或/且c-myc表达量高,肺癌患者预后差。结论:TCRP1及c-myc在舌癌及肺癌组织中高表达,且表达呈正相关,它们的表达量与患者预后呈负相关。
关 键 词: 肿瘤学;舌癌耐药相关蛋白1(TCRP1);c-myc;舌癌;肺癌;预后
Title: Expression of TCRP1 and c-myc in tongue and lung cancer
Author: JIA Xiaoting, ZHENG Guopei, HE Zhimin
Organization: Affiliated Cancer Hospital & Institute of Guangzhou Medical University
Abstract: Objective: To study the expression and function of tongue cancer-resistant protein 1 (TCRP1) and c-myc in tongue and lung cancer. Methods: 80 cases of tongue cancer tissues and 90 cases of lung cancer tissues were made into tissue microarray. The expression of TCRP1 and c-myc were measured via immunohistochemical analysis. The survival curves were made by Kaplan-Meier method. Finally, the correlationship between TCRP1/c-myc expression levels and prognosis of cancer patients was studied. Results: TCRP1 was highly expressed in 42 cases of 48 cases tongue cancer tissues with highly expressed c-myc. During 32 cases tongue cancer tissues with low c-myc, there was 12 cases highly expressed TCRP1. Survival curves showed that tongue cancer patients with high TCRP1 or/and high c-myc expression owned poor prognosis. 92.0% sample showed low TCRP1 in 38 cases of lung cancer tissues with low c-myc. 86.7% sample showed high TCRP1 in 52 cases of lung cancer tissues with high c-myc. Survival curves showed that lung cancer patients with high TCRP1 or/and high c-myc expression owned poor prognosis. Conclusion: TCRP1 and c-myc, negative prognostic biomarkers, were highly expressed and positively correlated with each other in tongue and lung cancers.
Key words: oncology; tongue cancer-resistant protein 1 (TCRP1); c-myc; tongue cancer; lung cancer; prognosis
发表期数: 2017年3月第5期
引用格式: 贾小婷,郑国沛,贺智敏. TCRP1及其调控因子c-myc在舌癌及肺癌中的表达[J]. 中国科技论文在线精品论文,2017,10(5):488-492.
 
0 评论数 0
暂无评论
友情链接