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TCRP1及其调控因子c-myc在舌癌及肺癌中的表达
发表时间：2017-03-15 浏览量：1662 下载量：316
| 全部作者： | 贾小婷，郑国沛，贺智敏 |
| 作者单位： | 广州医科大学附属肿瘤医院肿瘤研究所 |
| 摘 要： | 目的：探讨舌癌耐药相关蛋白1（tongue cancer-resistant protein 1，TCRP1）及其表达调控因子c-myc在舌癌及肺癌中的表达与临床意义。方法：将80例舌癌组织及90例肺癌组织制作成组织芯片，免疫组化检测TCRP1及c-myc的表达量，Kaplan-Meier方法制作生存曲线，分析TCRP1及c-myc的表达量与患者预后的相关性。结果：在48例高表达c-myc的舌癌组织中有42例高表达TCRP1，在32例低表达c-myc的舌癌组织中有12例高表达TCRP1. 生存曲线分析发现TCRP1表达量高或/且c-myc表达量高，舌癌患者预后差。在38例c-myc低表达的肺癌组织中有92.0%的组织也呈现TCRP1低表达，在52例c-myc高表达的肺癌组织中有86.7%的组织也呈现TCRP1高表达。生存曲线分析发现TCRP1表达量高或/且c-myc表达量高，肺癌患者预后差。结论：TCRP1及c-myc在舌癌及肺癌组织中高表达，且表达呈正相关，它们的表达量与患者预后呈负相关。 |
| 关 键 词： | 肿瘤学；舌癌耐药相关蛋白1（TCRP1）；c-myc；舌癌；肺癌；预后 |
| Title： | Expression of TCRP1 and c-myc in tongue and lung cancer |
| Author： | JIA Xiaoting, ZHENG Guopei, HE Zhimin |
| Organization： | Affiliated Cancer Hospital & Institute of Guangzhou Medical University |
| Abstract： | Objective: To study the expression and function of tongue cancer-resistant protein 1 (TCRP1) and c-myc in tongue and lung cancer. Methods: 80 cases of tongue cancer tissues and 90 cases of lung cancer tissues were made into tissue microarray. The expression of TCRP1 and c-myc were measured via immunohistochemical analysis. The survival curves were made by Kaplan-Meier method. Finally, the correlationship between TCRP1/c-myc expression levels and prognosis of cancer patients was studied. Results: TCRP1 was highly expressed in 42 cases of 48 cases tongue cancer tissues with highly expressed c-myc. During 32 cases tongue cancer tissues with low c-myc, there was 12 cases highly expressed TCRP1. Survival curves showed that tongue cancer patients with high TCRP1 or/and high c-myc expression owned poor prognosis. 92.0% sample showed low TCRP1 in 38 cases of lung cancer tissues with low c-myc. 86.7% sample showed high TCRP1 in 52 cases of lung cancer tissues with high c-myc. Survival curves showed that lung cancer patients with high TCRP1 or/and high c-myc expression owned poor prognosis. Conclusion: TCRP1 and c-myc, negative prognostic biomarkers, were highly expressed and positively correlated with each other in tongue and lung cancers. |
| Key words： | oncology; tongue cancer-resistant protein 1 (TCRP1); c-myc; tongue cancer; lung cancer; prognosis |
| 发表期数： | 2017年3月第5期 |
| 引用格式： | 贾小婷，郑国沛，贺智敏. TCRP1及其调控因子c-myc在舌癌及肺癌中的表达[J]. 中国科技论文在线精品论文，2017，10（5）：488-492. |
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