您的位置:首页 > 论文页面
猪苓多糖分散片的处方优化研究
发表时间:2017-03-15 浏览量:1746 下载量:261
全部作者: | 吴学祎,乜聘虎,张国伟 |
作者单位: | 河北大学中医学院 |
摘 要: | 目的:采用新型崩解剂和稀释剂作为辅料,探讨猪苓多糖(polyporus polysaccharide,PPS)分散片处方的最佳配比,缩短其崩解时限,提高其生物利用度。方法:针对低取代羟丙基纤维素(low-substituted hydroxypropyl cellulose,L-HPC)、交联聚乙烯吡咯烷酮(polyvinylpolypyrrolidone,PVPP)、羧甲基淀粉钠(sodium carboxymethyl starch,CMS-Na)、微晶纤维素(microcrystalline cellulose,MCC)4种辅料设计正交试验,按照湿法制粒压片并做质量检查(崩解时限、外观、片重差异、脆碎度、溶出度),分析数据,总结最佳配比。结果:分散片的最佳处方工艺为以L-HPC、CMS-Na、PVPP、MCC作为联合崩解剂,L-HPC:CMS-Na:PVPP:MCC=11:8:5:5(质量比). 制得的分散片崩解时间<10 min. 结论:按该处方制备的PPS分散片工艺稳定可行,适于临床需要。 |
关 键 词: | 中药学;猪苓多糖分散片;处方优化;制备工艺 |
Title: | Prescription optimization of polyporus polysaccharide dispersible tablet |
Author: | WU Xueyi, NIE Pinhu, ZHANG Guowei |
Organization: | College of Chinese Medicine, Hebei University |
Abstract: | Objective: We use new type of disintegrating agent and diluent to optimize the prescription of polyporus polysaccharide (PPS) dispersible tablet, in order to shorten its disintegration time and improve its bioavailability. Methods: According to the low-substituted hydroxypropyl cellulose (L-HPC), polyvinylpolypyrrolidone (PVPP), sodium carboxymethyl starch (CMS-Na), microcrystalline cellulose (MCC), we design the orthogonal test, use wet granulation, and check the quality of PPS dispersible tablet (appearance, tablet weight difference, disintegration time, brittle broken degree, dissolution). Then we analyze data and get the optimal proportion. Results: The best prescription of the dispersible tablets is as follows: L-HPC:CMS-Na:PVPP:MCC=11:8:5:5 (mass ratio). The disintegration time of the obtained dispersible tablets is less than 10 min. Conclusion: We obtain the best prescription of PPS dispersible tablets, which is stable and suitable for clinical use. |
Key words: | science of Chinese pharmacology; polyporus polysaccharide dispersible tablet; prescription optimization; preparation technology |
发表期数: | 2017年3月第5期 |
引用格式: | 吴学祎,乜聘虎,张国伟. 猪苓多糖分散片的处方优化研究[J]. 中国科技论文在线精品论文,2017,10(5):562-567. |

请您登录
暂无评论