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二级砜类化合物的合成新方法及其不对称合成研究

发表时间:2017-04-14  浏览量:2077  下载量:252
全部作者: 余雷
作者单位: 重庆大学药学院
摘 要: 提出通过Michael加成反应合成一系列二级砜类化合物的新方法。该方法以α,β-不饱合酮为共轭体系,苯亚磺酸为亲核试剂。反应条件温和,产率高,可通过直接过滤重结晶得到产物并成功将反应扩大至克级。利用手性开环冠醚催化剂,对二级砜类化合物的不对称合成进行探索。并对所合成化合物的化学结构通过核磁共振(nuclear magnetic resonance,NMR)氢谱、碳谱进行表征。
关 键 词: 有机化学;砜类化合物;不对称合成;Michael加成反应;α,β-不饱合酮
Title: New method for the synthesis of secondary sulfone derivatives and asymmetric synthesis studies
Author: YU Lei
Organization: School of Pharmaceutical Sciences, Chongqing University
Abstract: An effective approach to synthesis of secondary sulfone derivatives via Michael addition reaction was reported. In this reaction, using α,β-unsaturated ketones as conjugated system and arylsulfinic acid as nucleophile system. This method has advantages of mild reaction condition, high yield, and the product can be obtained after filtration and recrystallization and a gram-scale reaction was successfully performed. Exploration on asymmetric synthesis of secondary sulfones catalyzed by chiral cation-binding polyether catalyst was conducted. The chemical structures of the synthesized compounds were characterized by 1H and 13C nuclear magnetic resonance (NMR) spectroscopy.
Key words: organic chemistry; sulfone derivatives; asymmetric synthesis; Michael addition reaction; α,β-unsaturated ketones
发表期数: 2017年4月第7期
引用格式: 余雷. 二级砜类化合物的合成新方法及其不对称合成研究[J]. 中国科技论文在线精品论文,2017,10(7):777-784.
 
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