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砷的生殖毒性研究

发表时间:2017-09-15  浏览量:1094  下载量:152
全部作者: 殷帼英,曹德庆,李耀妍,刘娟,汤乃军,张强
作者单位: 天津医科大学公共卫生学院;天津医科大学公共卫生学院预防医学实验教学中心;天津医科大学图书馆
摘 要: 砷导致的生殖系统毒性已引起越来越多的关注,流行病学资料和动物实验均证实了砷对暴露者的生殖毒性作用。本文从生殖细胞、胚胎及激素水平的变化等方面分析总结近几年砷导致的人类及动物生殖毒性研究,包括砷暴露造成的精子数量及活力下降、精子畸形增加、睾丸组织结构受损、睾酮及黄体生成素等激素水平改变,以及母亲孕期砷暴露造成的流产、畸形、死胎及低出生体重儿等生殖毒性作用,从而能够对砷的生殖毒性效应有更深入的了解,为今后砷生殖毒性研究的开展奠定理论基础。
关 键 词: 毒理学;砷;综述;生殖细胞毒性;胚胎毒性;激素水平
Title: Study on reproductive toxicity of arsenic
Author: YIN Guoying, CAO Deqing, LI Yaoyan, LIU Juan, TANG Naijun, ZHANG Qiang
Organization: School of Public Health, Tianjin Medical University; Center Laboratory of Preventive Medicine, School of Public Health, Tianjin Medical University; Library of Tianjin Medical University
Abstract: Arsenic-induced reproductive system toxicity has attracted more and more attention. The study of epidemiological data and animal experiments have confirmed the effect of arsenic reproductive toxicity on exposure persons. This paper summarizes the arsenic-induced human and animal reproductive toxicity studies in recent years from the aspects of changes in germ cells, embryos and hormones, including decreased sperm counts and viability, increased sperm deformity, impaired testicular tissue structure, changed testosterone and luteinizing hormone levels, and miscarriage, deformity, stillbirth and low birth weight and other reproductive effects of children caused by maternal arsenic exposure, laying a theoretical foundation for the future study of arsenic reproductive toxicity.
Key words: toxicology; arsenic; review; germ cell toxicity; embryo toxicity; hormone level
发表期数: 2017年9月第17期
引用格式: 殷帼英,曹德庆,李耀妍,等. 砷的生殖毒性研究[J]. 中国科技论文在线精品论文,2017,10(17):1892-1899.
 
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