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IgA1异常糖基化和miRNAs在IgA肾病发病机制中的作用

发表时间:2017-09-15  浏览量:905  下载量:104
全部作者: 胡帅,鲍浩,刘志红
作者单位: 南京大学医学院附属金陵医院(南京军区南京总医院)肾脏科,国家肾脏疾病临床医学研究中心,全军肾脏病研究所
摘 要: IgA肾病(IgA nephropathy,IgAN)是以IgA1弥漫沉积在肾小球系膜区为主要病理特征的疾病。IgAN不仅是我国最常见的原发性肾小球疾病,也是导致终末期肾病(end-stage renal disease,ESRD)最常见的病因。近年来,对低糖基化IgA1(galactose-deficient IgA1,Gd-IgA1)及miRNAs在IgAN发病机制中作用的研究取得了较大进展,提高了人们对IgAN的理解。本文对Gd-IgA1和miRNAs在IgAN中的研究进展进行综述,为将来临床治疗奠定理论基础。
关 键 词: 肾脏病学;IgA肾病;综述;低糖基化IgA1;miRNAs
Title: Role of aberrantly glycosylated IgA1 and miRNAs in pathogenesis of IgA nephropathy
Author: HU Shuai, BAO Hao, LIU Zhihong
Organization: Research Institute of Nephrology, National Clinical Research Center of Kidney Diseases, Department of Nephrology, Jinling Hospital (Nanjing General Hospital), Medical School of Nanjing University
Abstract: IgA nephropathy (IgAN) is characterized by the diffuse deposition of IgA1 in mesangial area of glomerulus. IgAN is the most common primary glomerular disease, and also the major cause of end-stage renal disease (ESRD) in China. In recent years, great progress has been made in the research of galactose-deficient IgA1 (Gd-IgA1) and miRNAs in IgAN, which significantly improves our understanding on the pathogenesis of IgAN. In this paper, the progress of Gd-IgA1 and miRNAs in IgAN is reviewed, which establishes a theoretical foundation for future clinical treatment.
Key words: nephrology; IgA nephropathy; review; galactose-deficient IgA1; miRNAs
发表期数: 2017年9月第17期
引用格式: 胡帅,鲍浩,刘志红. IgA1异常糖基化和miRNAs在IgA肾病发病机制中的作用[J]. 中国科技论文在线精品论文,2017,10(17):1906-1912.
 
2 评论数 3

用户lavender:论文有新意,值得推荐。

2017-09-22 15:03:11

duantao0601:回复lavender:很棒!继续加油!

2017-09-22 15:06:43
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ly1504htkl:回复lavender:为将来临床治疗奠定理论基础

2017-09-22 15:06:42
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