您的位置:首页  > 论文页面

多取代四氢-β-咔啉类衍生物的合成研究

发表时间:2017-09-15  浏览量:919  下载量:121
全部作者: 董佳威,张敏
作者单位: 重庆大学药学院
摘 要: β-咔啉类生物碱是一类重要的吲哚生物碱,该类生物碱因为其在自然界中的广泛分布以及生物学活性的多样性而受到化学工作者们的广泛关注。研究报道了一类从市售可得的L-色氨酸出发,以Pictet-Spengler反应、Stille偶联等为关键反应高效制备2,3,9-位取代的四氢-β-咔啉类衍生物的方法。该方法为后续的β-咔啉类生物碱衍生物的生物活性研究奠定了坚实的基础。
关 键 词: 药物化学;四氢-β-咔啉;Pictet-Spengler反应;吲哚生物碱;抗肿瘤活性
Title: Study on the synthesis of polysubstituted tetrahydro-β-carboline derivatives
Author: DONG Jiawei, ZHANG Min
Organization: School of Pharmaceutical Sciences, Chongqing University
Abstract: The β-carboline alkaloid is an important type of indole alkaloids, and has attracted increasing interest of synthetic chemists, owing to its wide distribution in the nature as well as various significant biological activities. Herein, we report a synthesis study of chiral 2, 3, 9-trisubstituted-tetrahydro-β-carboline derivatives with commercially available L-tryptophan as the starting material, with Pictet-Spengler reaction and Stille coupling as the key steps. This study paves the base for the further biological studies of β-carboline alkaloid derivatives.
Key words: medicinal chemistry; tetrahydro-β-carboline; Pictet-Spengler reaction; indole alkaloids; antitumor activity
发表期数: 2017年9月第17期
引用格式: 董佳威,张敏. 多取代四氢-β-咔啉类衍生物的合成研究[J]. 中国科技论文在线精品论文,2017,10(17):1966-1971.
 
0 评论数 0
暂无评论
友情链接