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肿瘤相关巨噬细胞与卵巢癌病人不良预后的Meta分析

发表时间:2017-12-15  浏览量:803  下载量:102
全部作者: 郭轶,沈燕,李冰燕,张增利
作者单位: 苏州大学医学部公共卫生学院
摘 要: 目的:探究在卵巢癌病人中,肿瘤相关巨噬细胞的阳性率与病人预后的关系。方法:计算机检索PubMed与MEDLINE数据库中相关文章,由2名研究员独立筛选和评价文献,运用Stata 11.0软件对提取的数据进行Meta分析。结果:Meta分析纳入的8篇文献,包括来自北美及亚洲的961例病例。卵巢癌中高密度的肿瘤相关巨噬细胞与病人较差的预后有关[风险比(hazard ratio,HR) 1.78,95%CI (1.19, 2.66)]。亚组分析发现,高密度的M2型肿瘤相关巨噬细胞可以引起病人总生存率下降[HR 2.17,95%CI (1.58, 2.97)]。结论:Meta分析发现,肿瘤相关巨噬细胞、M2型肿瘤相关巨噬细胞与卵巢癌的不良预后有关。
关 键 词: 肿瘤学;肿瘤相关巨噬细胞;卵巢癌;肿瘤临床预后;肿瘤微环境
Title: Tumor-associated macrophages associated with poor prognosis of ovarian cancer patients: Meta-analysis
Author: GUO Yi, SHEN Yan, LI Bingyan, ZHANG Zengli
Organization: School of Public Health, Medical College of Soochow University
Abstract: Objective: To evaluate the association of tumor-associated macrophages (TAMs) positive percentage and prognosis in ovarian cancer patients. Methods: A systematic literature search was conducted via PubMed and MEDLINE database to identify eligible studies. Two reviewers independently screened and evaluated the included articles. Stata 11.0 software was used to analyze the data. Results: The Meta-analysis included 8 studies of 961 participants from North America and Asia. High generalized TAMs density was significantly associated with poor prognosis [hazard ratio (HR) 1.78, 95%CI (1.19, 2.66)]. Subgroup analysis revealed that high density of M2 TAMs was correlated with a poor prognosis for overall suivival [HR 2.17, 95%CI (1.58, 2.97)]. Conclusion: Meta-analysis indicates that TAMs and M2 TAMs are predicative factors of prognosis in ovarian cancer patients.
Key words: oncology; tumor-associated macrophages; ovarian cancer; tumor clinical prognosis; tumor microenvironment
发表期数: 2017年12月第23期
引用格式: 郭轶,沈燕,李冰燕,等. 肿瘤相关巨噬细胞与卵巢癌病人不良预后的Meta分析[J]. 中国科技论文在线精品论文,2017,10(23):2593-2599.
 
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