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间充质干细胞向肝样细胞分化机制研究进展

发表时间:2018-03-15  浏览量:1167  下载量:221
全部作者: 张泽亮,李汛
作者单位: 兰州大学第一临床医学院;兰州大学第一医院普外五科;甘肃省生物治疗与再生医学重点实验室;甘肃省肝胆胰研究所;兰州大学医学院肿瘤防治中心
摘 要: 间充质干细胞(mesenchymal stem cells,MSCs)是一种具有多向分化潜能的干细胞,且通过外周静脉、门静脉、肝动脉等多种途径将其输入终末期肝病患者体内可改善患者的肝功能,这一作用的发挥可能是由于MSCs在体内分化为肝样细胞从而改善了患者的肝功能,因此探明其向肝样细胞分化的具体机制并成功地诱导其向肝样细胞分化已成为当前亟待解决的关键问题之一。近年来,有关MSCs向肝样细胞分化的机制主要集中在以下说法,如间质向上皮转化(mesenchymal-to-epithelial transition,MET)、Raf/MEK/ERK信号通路、microRNAs、曲古抑菌素A(trichostatin A,TSA)等。本文综述当前有关MSCs向肝样细胞分化的机制,为更好地诱导其向肝样细胞分化打下坚实的理论基础。
关 键 词: 外科学;间充质干细胞;综述;肝样细胞;分化
Title: Mechanism advances of mesenchymal stem cells differentiating into hepatocyte-like cells
Author: ZHANG Zeliang, LI Xun
Organization: The First Clinical Medical College, Lanzhou University; The Fifth Department of General Surgery, The First Hospital of Lanzhou University; Gansu Province Key Laboratory of Biotherapy and Regenerative Medicine; Gansu Province Institute of Hepatopancreatobiliary; Tumor Control Center of Lanzhou University Medical College
Abstract: Mesenchymal stem cells (MSCs) are a kind of pluripotent stem cells owning multi-lineage differentiation potential. MSCs can improve the liver function of end-stage liver disease patients when they entered into the patients through peripheral veins, portal vein, hepatic artery, etc. This effect may due to the reason that MSCs differentiate into hepatocyte-like cells to improve the liver function of patients in vivo. So it is essential for us to explore the specific mechanisms of the differentiation and to successfully induce MSCs into hepatocyte-like cells. Recently, the detailed mechanisms how MSCs differentiate into hepatocyte-like cells are the following such as mesenchymal-to-epithelial transition (MET), Raf/MEK/ERK signaling pathway, microRNAs and trichostatin A (TSA). In this review, we summarized the current mechanisms related to MSCs differentiating into hepatocyte-like cells, and lay a solid theoretical basis to induce MSCs into hepatocyte-like cells better.
Key words: surgery; mesenchymal stem cells; review; hepatocyte-like cells; differentiation
发表期数: 2018年3月第5期
引用格式: 张泽亮,李汛. 间充质干细胞向肝样细胞分化机制研究进展[J]. 中国科技论文在线精品论文,2018,11(5):431-436.
 
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