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microRNA在神经元转分化中的作用

发表时间:2018-09-14  浏览量:150  下载量:39
全部作者: 孟必成,刘海亮
作者单位: 同济大学医学院再生医学系干细胞研究中心;同济大学附属同济医院干细胞临床转化中心
摘 要: 细胞转分化是指一种已分化细胞呈现出另一种已分化细胞特征的过程,不仅是转录因子,microRNA也可以实现细胞的转分化。目前,有关的研究主要集中于成纤维细胞和间充质干细胞在microRNA的作用下转分化为神经元,这种作用可以是促进性的,也可以是抑制性的。成纤维细胞和间充质干细胞作为比较容易获得的细胞资源,通过将它们转分化成神经元,可以大量解决临床需求,为临床转化奠定基础。因此,研究microRNA在星形胶质细胞转分化为神经元中的作用,将有比较重要的科学意义。
关 键 词: 医学细胞生物学;microRNA;综述;转分化;神经元
Title: Role of microRNA in the transdifferentiation of other cells into neurons
Author: MENG Bicheng, LIU Hailiang
Organization: Stem Cell Research Center, Department of Regenerative Medicine, Tongji University School of Medicine; Translational Stem Cell Research Center, Tongji Hospital, Tongji University School of Medicine
Abstract: Cell transdifferentiation reflects a process in which a differentiated cell exhibits the identity of another differentiated cell. Not only transcription factor, but microRNA can achieve this process. The current studies focuse on the role of microRNAs during transdifferentiation from fibroblasts or mesenchymal stem cells to neurons, and this effect can be promoted or inhibited. Because fibroblasts and mesenchymal stem cells are relatively easy to obtain, they can solve a large number of clinical needs and establish a good foundation for clinical transformation by transdifferentiation them into neurons. Therefore, the role of microRNA in the transdifferentiation of astrocytes into neurons will have a more important scientific significance.
Key words: medical cell biology; microRNA; review; transdifferentiation; neuron
发表期数: 2018年9月第17期
引用格式: 孟必成,刘海亮. microRNA在神经元转分化中的作用[J]. 中国科技论文在线精品论文,2018,11(17):1708-1712.
 
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