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细胞融合在肿瘤转移中作用的研究进展

发表时间:2018-12-14  浏览量:161  下载量:18
全部作者: 姜二辉,晏挺林,黄春明,陈洋,王慧,尚政军
作者单位: 武汉大学口腔医院
摘 要: 细胞融合是两个或两个以上细胞发生胞膜融合形成一个新细胞的过程,是机体在生理和病理状态下普遍发生的一种生命现象。肿瘤的发生、发展是一种由多机制调控、多分子参与的复杂病理过程,肿瘤转移是肿瘤发展过程中的一种现象,是判断肿瘤恶性程度的重要指征,与病人的预后和生存息息相关。细胞融合与肿瘤干细胞形成、肿瘤高侵袭性获得、肿瘤微环境改造、上皮细胞间充质转化(epithelial-mesenchymal transition,EMT)、肿瘤耐药性以及肿瘤血管形成等现象密切相关,参与肿瘤的发生、生长、侵袭和转移等过程。本文总结细胞融合在肿瘤转移中作用的研究进展,为肿瘤治疗提供目标和方向。
关 键 词: 肿瘤学;细胞融合;综述;肿瘤转移;肿瘤干细胞;肿瘤微环境
Title: Research progress on the role of cell fusion in tumor metastasis
Author: JIANG Erhui, YAN Tinglin, HUANG Chunming, CHEN Yang, WANG Hui, SHANG Zhengjun
Organization: School of Stomatology, Wuhan University
Abstract: Cell fusion is the process of the membrane fusion of two or more cells to form a new cell, which is a kind of life phenomenon common in the organism under both physiological and pathological conditions. The occurrence and development of tumor is a complex pathological process which is regulated by multiple mechanisms and involved in multiple molecules. Tumor metastasis is a common phenomenon during the development of tumor. It is an important indication of determining tumor malignancy, which is closely related to the prognosis and survival of the patient. Cell fusion strongly participates in tumor stem cell formation, high invasiveness acquisition of tumor, modification of tumor microenvironment, epithelial-mesenchymal transition (EMT), drug resistance and tumor angiogenesis, which are closely related to the development, growth, invasion and metastasis of tumor. This paper intends to summarize the research progress on the role of cell fusion in tumor metastasis, and provide target and direction for tumor treatment.
Key words: oncology; cell fusion; review; tumor metastasis; tumor stem cells; tumor microenvironment
发表期数: 2018年12月第23期
引用格式: 姜二辉,晏挺林,黄春明,等. 细胞融合在肿瘤转移中作用的研究进展[J]. 中国科技论文在线精品论文,2018,11(23):2332-2337.
 
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