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多囊卵巢综合征患者血清脂联素水平与颈动脉内膜中层厚度的关系

发表时间:2018-12-14  浏览量:461  下载量:23
全部作者: 陈亚肖,狄娜,黄佳,杨冬梓
作者单位: 中山大学孙逸仙纪念医院妇产科
摘 要: 目的:探讨多囊卵巢综合征(polycystic ovary syndrome,PCOS)患者血清脂联素水平与颈动脉内膜中层厚度(intima-media thickness,IMT)的关系。方法:纳入初诊初治的PCOS 患者214 例,根据颈动脉IMT分为颈动脉正常组(n=114)和颈动脉增厚组(n=100),检测所有患者的血清脂联素水平,比较两组间的血清脂联素水平及其与颈动脉IMT的相关性。结果:两组患者的年龄和体重指数(body mass index,BMI)匹配,颈动脉增厚组的血清脂联素水平低于颈动脉正常组[(5.1±2.4) mg/L vs (7.8±3.1) mg/L,P=0.04],相关分析显示颈动脉IMT与血清脂联素水平呈负相关性(r=−0.337,P=0.001)。二分类回归分析显示,脂联素与经典的动脉粥样硬化危险因素如年龄、血压等共同纳入回归方程(P<0.05),显示血清脂联素水平(OR=0.701,95%CI 0.55~0.87,P<0.01)对颈动脉IMT增加有一定的影响作用。结论:PCOS患者颈动脉IMT与血清脂联素水平具有相关性,颈动脉IMT增厚者的血清脂联素水平低,且脂联素是PCOS患者颈动脉IMT增加的独立影响因素之一。
关 键 词: 妇产科学;多囊卵巢综合征;脂联素;颈动脉内膜中层厚度
Title: Relationship of serum adiponectin level and carotid intima-media thickness in patients with polycystic ovary syndrome
Author: CHEN Yaxiao, DI Na, HUANG Jia, YANG Dongzi
Organization: Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University
Abstract: Objective: To explore the relationship of serum adiponectin level and carotid intima-media thickness (IMT) in patients with polycystic ovary syndrome (PCOS). Methods: The study involved 214 PCOS patients with preliminary diagnosis and initial treatment, who were divided into carotid normal group (n=114) and carotid thickening group (n=100), according to the carotid IMT. All patients were detected serum adiponectin level. Comparisons of serum adiponectin level and its correlation with carotid IMT between the two groups were carried out. Results: Age and body mass index (BMI) matched in both groups. Serum adiponectin level was lower in carotid thickening group than that in carotid normal group [(5.1±2.4) mg/L vs (7.8±3.1) mg/L, P=0.04], correlation analysis showed that serum adiponectin level was negatively associated with carotid IMT (r=−0.337, P=0.001). Binary classification regression analysis showed that adiponectin and classic risk factors of atherosclerosis, such as age and blood pressure, entered the regression equation (P<0.05). Serum adiponectin level (OR=0.701, 95%CI 0.55-0.87, P<0.01) had a certain effect on the increase of carotid IMT. Conclusion: Serum adiponectin level and carotid IMT were correlated in PCOS patients. Serum adiponectin level was low in carotid IMT thickening group and was one of the independent determinants of increasing carotid IMT.
Key words: obstetrics and gynecology; polycystic ovary syndrome (PCOS); adiponectin; carotid intima-media thickness (IMT)
发表期数: 2018年12月第23期
引用格式: 陈亚肖,狄娜,黄佳,等. 多囊卵巢综合征患者血清脂联素水平与颈动脉内膜中层厚度的关系[J]. 中国科技论文在线精品论文,2018,11(23):2353-2356.
 
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