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中性粒细胞胞外诱捕网研究进展

发表时间:2019-03-22  浏览量:883  下载量:68
全部作者: 周协琛,武瑞,王海,贺显晶
作者单位: 黑龙江八一农垦大学动物科技学院
摘 要: 多形核中性粒细胞(poly-morphonuclear neutrophils,PMN)是机体天然免疫系统中第一条防线的重要组分。以往研究发现,PMN杀灭病原微生物主要通过其脱颗粒及吞噬作用。最近发现一种新的方式——中性粒细胞通过释放自身裂解的DNA形成网状结构,使多种蛋白镶嵌在网状结构上,形成中性粒细胞胞外诱捕网(neutrophil extracellular traps,NETs),包裹病原微生物并对其进行杀灭。研究表明,NETs的出现对机体而言是一把双刃剑,NETs有利于机体杀灭病原微生物,且是自身免疫性疾病的强诱发因素,可导致各种急慢性炎症性疾病的发生。本文就NETs的形成、影响因素及其与机体自身免疫性疾病的关系作一概述。
关 键 词: 动物医学;中性粒细胞;综述;胞外诱捕网;杀菌作用;自身免疫性疾病
Title: Progress in neutrophil extracellular traps
Author: ZHOU Xiechen, WU Rui, WANG Hai, HE Xianjing
Organization: College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University
Abstract: Poly-morphonuclear neutrophils (PMN) as the main members in the innate immune system form the first line of defense. Previous studies have found that PMN killed pathogenic microorganisms mainly by their degranulation and phagocytosis. Recently, another new mechanism has been discovered, which neutrophils form a network structure by releasing self-cleaved DNA, and a variety of proteins are embedded in the network to form neutrophil extracellular traps (NETs), enveloping pathogens and killing them. However, research has shown that NETs are actually a double-edged sword. NETs not only are conducive to host in killing pathogenic microorganisms, but also strongly cause autoimmune diseases, which can lead to various acute and chronic inflammatory diseases. This article reviews the formation, influenced factors of NETs and their relationship with autoimmune diseases.
Key words: veterinary medicine; neutrophils; review; extracellular traps; bactericidal effect; autoimmune disease
发表期数: 2019年2月第1期
引用格式: 周协琛,武瑞,王海,等. 中性粒细胞胞外诱捕网研究进展[J]. 中国科技论文在线精品论文,2019,12(1):127-131.
 
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