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膜攻击复合物在年龄相关性黄斑变性中致病作用的研究进展

发表时间:2019-03-22  浏览量:477  下载量:57
全部作者: 杨伟,吴绵绵,孙靖,张琰,张红
作者单位: 天津医科大学眼科医院,天津医科大学眼科研究所,天津医科大学眼视光学院
摘 要: 年龄相关性黄斑变性(age-related macular degeneration,AMD)是老年人视力不可逆性丧失的最常见眼科疾病,非渗出性约占90%,渗出性约占10%. AMD的病因和机制复杂,已有研究表明,免疫补体的调节失衡与AMD发生密切相关。“地图状萎缩斑”是非渗出性AMD的特征,同时伴随着视网膜色素上皮(retinal pigment epithelium,RPE)细胞的凋亡和丢失,以及感光细胞的萎缩变性。脉络膜新生血管(choroidal neovascularization,CNV)是渗出性AMD最明显的特征。膜攻击复合物(membrane attack complex,MAC)是补体系统激活的最终产物。近年来的研究发现其在AMD的发展中扮演着重要角色。本文将对MAC与RPE的萎缩凋亡、CNV形成的关系,以及通过抑制MAC沉积治疗渗出性和非渗出性AMD的研究进展加以综述,为AMD的研究、治疗开辟新思路。
关 键 词: 眼科学;年龄相关性黄斑变性;综述;膜攻击复合物;免疫补体;脉络膜新生血管
Title: Research advances on the role of membrane attack complex in the pathogenesis of age-related macular degeneration
Author: YANG Wei, WU Mianmian, SUN Jing, ZHANG Yan, ZHANG Hong
Organization: Tianjin Medical University Eye Hospital, Tianjin Medical University Eye Institute, School of Optometry and Ophthalmology, Tianjin Medical University
Abstract: Age-related macular degeneration (AMD) is the leading ophthalmological disease in irreversible loss of vision among the elderly. Approximately 90% of AMD patients suffer from non-exudative form of AMD, and the remaining AMD patients suffer from exudative form of AMD. The cause and mechanism of AMD is very complex, but numerous study indicate that the imbalance regulation of complement has an intimated relationship with AMD. “Geographic atrophy” is the feature of non-exudative AMD, with the loss and apoptosis of retinal pigment epithelium (RPE) cells and the atrophy and degeneration of photoreceptors. Choroidal neovascularization (CNV) is the foremost feature of exudative AMD. Membrane attack complex (MAC) is the final product of the activated complement cascade. Recently study has found that MAC plays an important role in the development of AMD. In this article, we will review the relationship between MAC and the apoptosis of RPE, the formation of CNV, and the study progress of inhibiting the deposition of MAC to treat exudative and non-exudative AMD, in order to explore a new thought for the therapy of AMD and its application.
Key words: ophthalmology; age-related macular degeneration; review; membrane attack complex; immune complement; choroidal neovascularization
发表期数: 2019年2月第1期
引用格式: 杨伟,吴绵绵,孙靖,等. 膜攻击复合物在年龄相关性黄斑变性中致病作用的研究进展[J]. 中国科技论文在线精品论文,2019,12(1):132-139.
 
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