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非镇痛药物完全缓解晚期恶性肿瘤疼痛研究
发表时间：2019-03-22 浏览量：3321 下载量：620
| 全部作者： | 韩祖良 |
| 作者单位： | 三亚海棠湾韩祖良诊所 |
| 摘 要： | 目的：应用化疗药物、生物制剂及中药，观察晚期恶性肿瘤疼痛获得完全缓解的疗效。方法：将63例晚期恶性肿瘤患者随机分成两组；治疗组32例患者应用化疗药物、生物制剂及中药，对照组31例患者应用化疗药物和中枢镇痛药物，观察两组患者疼痛完全缓解情况，包括有效止痛的疗效、停药后疼痛的反弹率以及不良反应的发生率。疗程6周，停药观察4周。结果：1）治疗组27例/32例（84.38%）患者，对照组26例/ 31例（83.87%）患者获得有效止痛的疗效，2＝0.084 1，P＞0.05，无显著差异，但治疗组有25例/32例（78.13%）患者，对照组仅有7例/31例（22.58%）患者获得疼痛完全缓解的疗效，2＝19.476 6，P＜0.01，有非常显著差异；2）治疗组25例获得疼痛完全缓解的患者，在观察期内无一例出现疼痛反弹，而对照组12例中有5例患者，在观察期内发生疼痛反弹，最终仅有7例患者获得疼痛完全缓解的疗效；3）治疗组除个别患者偶有出现发烧及疲乏症状外，无其他任何不良反应，而对照组全部患者分别显示有不同程度的便秘、嗜睡、眩晕、恶心及呕吐等不良反应。结论：化疗药物、生物制剂及中药适用于晚期恶性肿瘤患者癌性疼痛的治疗，并有疗效显著、安全、无不良反应及疼痛不反弹等优势。 |
| 关 键 词： | 肿瘤学；晚期恶性肿瘤；非镇痛药物；疼痛；完全缓解；无毒副作用 |
| Title： | Study of non-analgesic drugs to completely relieve the pain of advanced malignant tumors |
| Author： | HAN Zuliang |
| Organization： | Sanya Haitang Bay Han Zuliang Medical Clinic |
| Abstract： | Objective: Application of chemotherapeutic drugs, biological agents and traditional Chinese medicine to observe the efficacy of complete pain relief in advanced malignant tumors. Methods: Sixty-three patients with advanced malignant tumors were randomly divided into two groups. Thirty-two patients in treatment group received chemotherapeutic drugs, biological agents and traditional Chinese medicine. Thirty-one patients in control group received only chemotherapeutic drugs and central analgesic drugs. Complete pain relief was observed in both groups, including the efficacy of effective pain relief, the rate of pain rebound after withdrawal, and the incidence of adverse reactions. The course of treatment was 6 weeks, and drug withdrawal was observed for 4 weeks. Results: 1) Both treatment and control groups reported effective analgesic results. Effectiveness between treatment and control groups were 84.38% (27/32) vs 83.87% (26/31). 2 was 0.084 1, P>0.05. There was no significant difference. However, there was a very significant difference between the two groups in the efficacy of complete pain relief: 78.13% (25/32) in the treatment group vs 22.58% (7/31) in the control group, 2 =19.476 6, P<0.01. 2) Among the 25 patients who had complete pain relief, there was no a single case of pain rebound during the observation period, while 5 of the 12 patients had pain rebounded in the control group. In all, only 7 patients reported complete pain relief. 3) The treatment group had no obviously adverse effects except for occasional fever and fatigue symptoms in individual patients, while in the control group, all patients presented with varying degrees of constipation, sleepiness, dizziness, nauseous and vomiting. Conclusion: Chemotherapeutic drugs, biological agents and traditional Chinese medicine were suitable for the treatment of cancer pain in patients with advanced malignant tumors, which had the advantages of obvious efficacy, safety, no adverse reactions and no pain rebound. |
| Key words： | oncology; advanced malignant tumor; non-analgesic drug; pain; complete relief; non-toxic side effects |
| 发表期数： | 2019年2月第1期 |
| 引用格式： | 韩祖良. 非镇痛药物完全缓解晚期恶性肿瘤疼痛研究[J]. 中国科技论文在线精品论文，2019，12（1）：149-155. |
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