您的位置:首页  > 论文页面

天然产物O-甲基转移酶应用的研究进展

发表时间:2019-08-30  浏览量:223  下载量:26
全部作者: 周林俊,瞿旭东
作者单位: 武汉大学药学院,
摘 要: 甲基化是所有生命体中普遍存在的反应,通常由S-腺苷甲硫氨酸(S-adenosyl-L-methionine,SAM)依赖的甲基转移酶催化完成。O-甲基转移酶(O-methyltransferases,OMTs)是天然产物甲基转移酶家族中数量最庞大的一类,通过对分子中的羟基或羧羟基氧原子进行甲基化修饰,OMTs可以极大地改善天然产物的性质。目前,天然产物OMTs(natural product OMTs,NPOMTs)已经广泛应用于医药、化工和能源等诸多领域,展现出了巨大的应用价值和广阔的应用前景。本文从精细化学品生产、生物活性分子合成及生物柴油合成三个方面对NPOMTs的应用进行综述,以期为NPOMTs的进一步发展提供有益借鉴。
关 键 词: 分子生物学;天然产物;综述;O-甲基转移酶;应用
Title: Application progress of natural product O-methyltransferases
Author: ZHOU Linjun, QU Xudong
Organization: School of Pharmaceutical Sciences, Wuhan University
Abstract: Methylation is a ubiquitous reaction in all living organisms, which is usually catalyzed by S-adenosyl-L-methionine (SAM) dependent methyltransferases. O-methyltransferases (OMTs) are the most abundant natural product methyltransferase. By methylating hydroxyl or carboxyhydroxyl oxygen atoms in the molecule, OMTs can greatly improve the properties of natural products. At present, the natural product OMTs (NPOMTs) have been widely used in many fields such as medicine, chemical industry and energy, and showing great application value and broad application prospects. In this paper, the application of NPOMTs was reviewed from three aspects: fine chemical production, bioactive molecular synthesis and biodiesel synthesis in order to provide useful reference for their further development.
Key words: molecular biology; natural product; review; O-methyltransferases; application
发表期数: 2019年8月第4期
引用格式: 周林俊,瞿旭东. 天然产物O-甲基转移酶应用的研究进展[J]. 中国科技论文在线精品论文,2019,12(4):610-622.
 
1 评论数 0
暂无评论
友情链接