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复方苦参注射液抗肿瘤作用机制及临床应用
发表时间：2021-09-30 浏览量：717 下载量：98
| 全部作者： | 张琬莹，张国伟 |
| 作者单位： | 河北大学中医学院 |
| 摘 要： | 复方苦参注射液（compound Kushen injection，CKI）作为一种中药制剂，已有25年的临床应用历史，可单独使用或与放化疗等其他的治疗手段联合应用，广泛用于胃癌、肺癌、肝癌、膀胱癌等多种恶性肿瘤的治疗，具有疗效好、不良反应少、安全性高、不易产生耐药性等优点。CKI能够通过诱导肿瘤细胞凋亡和自噬、阻滞细胞周期、抑制能量代谢和新生血管生成、调节机体免疫系统等多环节，发挥其抗癌作用。本文旨在对CKI的临床应用及抗肿瘤分子机制的研究现状做一综述，以期为后续研究提供理论支持。 |
| 关 键 词： | 中药学；复方苦参注射液；综述；恶性肿瘤；分子机制；临床应用 |
| Title： | Anti-tumor mechanism of compound Kushen injection and its clinical application |
| Author： | ZHANG Wanying, ZHANG Guowei |
| Organization： | College of Traditional Chinese Medicine, Hebei University |
| Abstract： | Compound Kushen injection (CKI), as a Chinese medicine preparation, has a history of 25 years of clinical application. It can be used alone or in combination with other treatments such as radiotherapy and chemotherapy, and has been widely used in the treatment of gastric cancer, lung cancer, liver cancer, bladder cancer and other malignant tumors. It has the advantages of good curative effect, few adverse reactions, high safety, and resistance to drug resistance. CKI plays an anti-cancer role by inducing apoptosis and autophagy of tumor cells, blocking cell cycle, inhibiting energy metabolism and angiogenesis, and regulating immune system. This paper aims to review the current research status of CKI’s clinical application and anti-tumor molecular mechanism, providing theoretical support for follow-up research. |
| Key words： | science of Chinese pharmacology; compound Kushen injection; review; malignant tumor; molecular mechanism; clinical application |
| 发表期数： | 2021年9月第3期 |
| 引用格式： | 张琬莹，张国伟. 复方苦参注射液抗肿瘤作用机制及临床应用[J]. 中国科技论文在线精品论文，2021，14（3）：272-285. |
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